CpG-ODN Shapes Alum Adjuvant |
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Vaxjo ID |
324 |
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Vaccine Adjuvant Name |
CpG-ODN Shapes Alum Adjuvant |
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Description |
Alum is described as aluminum-containing adjuvants and a T helper type-2 (Th2) adjuvant. CpG-ODN is described as a synthetic TLR9 agonist, composed of oligodeoxynucleotides containing CpG motifs. The study investigates how CpG-ODN shapes Alum adjuvant activity. |
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Stage of Development |
Research |
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Host Species for Testing |
3 |
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Structure |
Alum is described as "Aluminum-containing adjuvants." CpG-ODN is described as "oligodeoxynucleotides containing CpG motifs." |
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Preparation |
The paper mentions "sensitization with the synthetic TLR9 agonist, which is composed of oligodeoxynucleotides containing CpG motifs adsorbed to Alum," but detailed preparation methods are not provided. |
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Dosage |
The paper refers to "sensitization with OVA/Alum/CpG" but does not specify dosages. |
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Function |
Aluminum-containing adjuvants usually referred as Alum are considered as T helper type-2 (Th2) adjuvants, while agonists of toll-like receptors (TLRs) are viewed as adjuvants that favor Th1/Th17 immunity. Alum has been used in numerous vaccine formulations |
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Safety |
The paper discusses Alum's "undesired pro-Th2 adjuvant activity" and notes that in certain conditions in mice, OVA/Alum/CpG sensitization can result in "neutrophilic lung inflammation associated with IFN纬 production" or "neutrophilic inflammation dominated by IL-17 production." |
| References |
Mirotti et al., 2017: Mirotti L, Alberca Custódio RW, Gomes E, Rammauro F, de Araujo EF, Garcia Calich VL, Russo M. CpG-ODN Shapes Alum Adjuvant Activity Signaling via MyD88 and IL-10. Frontiers in immunology. 2017; 8; 47. [PubMed: 28220116].
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