HBcAg |
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Vaxjo ID |
313 |
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Vaccine Adjuvant Name |
HBcAg |
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Adjuvant VO ID |
VO_0005617
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Description |
A non-human hepadnaviral adjuvant derived from stork hepatitis B virus core gene-sequences, used in hepatitis C virus-based genetic vaccines. It is designed to enhance HCV-specific IFN-纬 and IL-2 responses and induce long-term functional memory T cell responses, avoiding potential interference from pre-existing immunity to human HBV. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
Human hepatitis B virus (HBV) core antigen (HBcAg) can act as an adjuvant in hepatitis C virus (HCV)-based DNA vaccines. |
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Structure |
Full-length and fragmented gene-sequences. |
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Preparation |
Full-length and fragmented stork HBcAg gene-sequences were added to an HCV non-structural (NS) 3/4A gene to create NS3/4A-stork-HBcAg. |
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Function |
The NS3/4A-stork-HBcAg vaccine enhanced HCV-specific IFN-γ and IL-2 responses in both normal and NS3/4A-transgenic mice with dysfunctional T cells. Repeated doses boosted these T cell responses and induced long-term memory dependent on CD4(+) T cells. Thus, stork-derived avian HBcAg sequences serve effectively as a DNA vaccine adjuvant. |
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Safety |
The adjuvant "completely avoids the use of sequences from a human virus where a pre-existing immunity may interfere with its adjuvant effect", implying a safety advantage by circumventing potential immune interference. |
| References |
Levander et al., 2016: Levander S, Sällberg M, Ahlén G, Frelin L. A non-human hepadnaviral adjuvant for hepatitis C virus-based genetic vaccines. Vaccine. 2016; 34(25); 2821-2833. [PubMed: 27109565].
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