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Cry proteins |
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Vaxjo ID |
312 |
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Vaccine Adjuvant Name |
Cry proteins |
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Adjuvant VO ID |
VO_0005270
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Description |
Cry proteins are insecticidal proteins derived from Bacillus thuringiensis (Bt) which are expressed in genetically modified (GM) crops to impart insect resistance. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
Plant expression of Bacillus thuringiensis (Bt) crystal (Cry) |
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Function |
Plant expression of Bacillus thuringiensis (Bt) crystal (Cry) insecticidal proteins have been the primary way to impart insect resistance in GM crops |
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Safety |
The paper concludes that Cry proteins are deemed safe by regulatory agencies globally and are unlikely to function as adjuvants, based on critical review of published literature, history of safe use in foods, safety of Bt donor organisms, and pre-market safety assessments for GM crops. |
| Related Vaccine(s) |
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| References |
Joshi et al., 2016: Joshi SS, Barnett B, Doerrer NG, Glenn K, Herman RA, Herouet-Guicheney C, Hunst P, Kough J, Ladics GS, McClain S, Papineni S, Poulsen LK, Rascle JB, Tao AL, van Ree R, Ward J, Bowman CC. Assessment of potential adjuvanticity of Cry proteins. Regulatory toxicology and pharmacology : RTP. 2016; 79; 149-155. [PubMed: 27105772].
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