Ophiopogonin D |
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Vaxjo ID |
295 |
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Vaccine Adjuvant Name |
Ophiopogonin D |
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Alternative Names |
Ophiopogonin D is also known as OP-D. |
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Adjuvant VO ID |
VO_0005660
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Description |
Ophiopogonin D is the chief pharmacologically active component of Radix Ophiopogonis, known for its immunopotentiating properties. It enhances immune responses when formulated with vaccines. |
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Stage of Development |
Research |
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Host Species for Testing |
3 |
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Components |
Ophiopogonin D, among dozens of natural products and then used nanotechnology to construct a highly efficient and low toxic adjuvant system (NOD) |
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Structure |
Ophiopogonin D has a monodesmoside structure, which is considered the active center for its adjuvant activity. |
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Appearance |
Ophiopogonin D is described as a turbid suspension when not encapsulated. The appearance of the nanoemulsion encapsulating OP-D is clear and transparent. |
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Preparation |
Ophiopogonin D was encapsulated in a nanoemulsion using low-energy emulsification methods based on a pseudo-ternary phase diagram. |
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Dosage |
The optimal immunization dose of Ophiopogonin D was determined to be 30 碌g per mouse in the study. |
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Function |
We first identified a new powerful immunopotentiator, Ophiopogonin D, among dozens of natural products and then used nanotechnology to construct a highly efficient and low toxic adjuvant system (NOD). Our approach intersects natural medicinal chemistry, nanomaterials and immunology, revealing that a strong adjuvant activity of this adjuvant system was verified in vitro and in vivo, and the application of MRSA subunit vaccine model for survival experiments achieved a 100% protection rate. This research illustrate that NOD is a promising and robust adjuvant platform for subunit vaccines. |
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Safety |
The article indicates that Ophiopogonin D has cytotoxic effects, but when encapsulated in a nanoemulsion, it exhibited reduced toxicity and improved safety in animal models. |
| References |
Tong et al., 2018: Tong YN, Yang LY, Yang Y, Song Z, Peng LS, Gao JN, Zeng H, Zou QM, Sun HW, Mao XH. An immunopotentiator, ophiopogonin D, encapsulated in a nanoemulsion as a robust adjuvant to improve vaccine efficacy. Acta biomaterialia. 2018; 77; 255-267. [PubMed: 30031164].
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