GC@ICG nanoparticle |
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Vaxjo ID |
279 |
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Vaccine Adjuvant Name |
GC@ICG nanoparticle |
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Alternative Names |
Glycated chitosan with indocyanine green |
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Adjuvant VO ID |
VO_0005767
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Description |
A self-assembled nanoparticle composed of amphiphilic glycated chitosan (GC) and indocyanine green (ICG), used for photo-immunotherapy in triple-negative breast cancer (TNBC). Acts as a “Trojan Horse” for tumor cell uptake and immune activation |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
Herein, we employed glycated chitosan (GC), a polysaccharide macromolecular immunoadjuvant, to construct a self-assembly GC@ICG nanoparticle which is accessible to tumor cells for synergistic cancer treatment based on the combination of phototherapy and immunotherapy. |
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Structure |
Nanoparticles (~208 nm), spherical, amphiphilic polymer with 5β-cholanic acid-modified GC encapsulating ICG |
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Appearance |
Spherical particles; good dispersion and uniformity under SEM |
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Storage |
Stored in deionized water; stable for at least 10 days across pH 5.5–7.4 |
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Preparation |
Synthesized via EDC/NHS-mediated coupling of 5β-cholanic acid to GC, followed by sonication with ICG and purification via centrifugation and dialysis |
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Dosage |
ICG: 20 µg/mL; GC: 1% in 100 µL i.v. injection; treated tumors irradiated with 808 nm laser at 0.8 W/cm² for 10 min |
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Function |
effective treatment methods are urgently needed to control primary tumors and suppress distant tumors. Herein, we employed glycated chitosan (GC), a polysaccharide macromolecular immunoadjuvant, to construct a self-assembly GC@ICG nanoparticle which is accessible to tumor cells for synergistic cancer treatment based on the combination of phototherapy and immunotherapy |
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Safety |
Well-tolerated, no death or weight loss observed; no systemic toxicity within 7 days post-treatment |
| References |
Wu et al., 2022: Wu J, Wang S, Liu S, Liu F, Zhou F. Immunoadjuvant Nanoparticles as Trojan Horses for Enhanced Photo-Immunotherapy in the Treatment of Triple-Negative Breast Cancer. Frontiers in pharmacology. 2022; 13; 883428. [PubMed: 35600886].
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