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Gel-gffy |
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Vaxjo ID |
277 |
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Vaccine Adjuvant Name |
Gel-gffy |
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Adjuvant VO ID |
VO_0005608
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Description |
A self-assembling peptide hydrogel (sequence: GFFY) used as a slow-release, biocompatible adjuvant to enhance antitumor immunity. Induces Th1-biased immune response (↑ IFN-γ, IL-2, CD8⁺ T cells) when combined with peptide antigens (e.g., TRP2). |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
self-assembling D-tetra-peptide named Nap-GDFDFDY (Gel-gffy) |
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Structure |
Short peptide GFFY (Gly-Phe-Phe-Tyr) that self-assembles into nanofibers, forming a gel matrix |
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Function |
We designed and synthesized five Gel-gffy variants (Sol-gfgy, Sol-ggfy, Gel-gffg, Gel-gfyf, and Gel-gyff) by substituting the phenylalanine and tyrosine to glycine or changing the position of the tyrosine in the parent D-tetra-peptide. First, we characterized their gelation properties, nanomorphology, and secondary structure using transmission electron microscopy and circular dichroism; next, we examined their immunostimulatory properties. |
| References |
Zhang et al., 2022: Zhang Y, Hu Z, Li X, Ding Y, Zhang Z, Zhang X, Zheng W, Yang Z. Amino acid sequence determines the adjuvant potency of a D-tetra-peptide hydrogel. Biomaterials science. 2022; 10(12); 3092-3098. [PubMed: 35522938].
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