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EGCG |
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Vaxjo ID |
262 |
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Vaccine Adjuvant Name |
EGCG |
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Alternative Names |
Epigallocatechin-3-gallate Green tea catechin |
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Adjuvant VO ID |
VO_0005749
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Description |
EGCG is a polyphenolic compound from green tea with known antioxidant, virucidal, and immunomodulatory properties. It promotes antibody production, IgG subclass switching, and ADCC activity when used as a vaccine adjuvant. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
Green tea catechins, especially epigallocatechin-3-gallate (EGCG), have been associated with cancer prevention and treatment. |
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Structure |
Aromatic polyphenol Contains 3-galloyl group, important for biological activity Chemical structure provided in the paper |
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Molecular Weight |
458 Da |
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Appearance |
Light green powder (as typical for purified EGCG ≥98%) |
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Storage |
Stored in powder form Reconstituted in distilled water for use |
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Preparation |
Purchased as ≥98% purity powder Dissolved in distilled water before mixing with antigens |
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Dosage |
70–700 µg per dose in mice Given IM or IP, three times, every 2 weeks |
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Function |
In a mouse model, the coadministration of epigallocatechin-3-gallate (EGCG) with influenza hemagglutinin (HA) antigens induced high levels of neutralizing antibodies, comparable to that induced by alum, providing complete protection against the lethal challenge. adjuvant effects were observed for all types of HA antigens, including recombinant full-length HA and HA1 globular domain, and egg-derived inactivated split influenza vaccines. |
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Safety |
Safe in mice |
| References |
Cheong et al., 2021: Cheong Y, Kim M, Ahn J, Oh H, Lim J, Chae W, Yang SW, Kim MS, Yu JE, Byun S, Jang YH, Seong BL. Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant. Frontiers in immunology. 2021; 12; 769088. [PubMed: 34868027].
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