Fuc-Sc |
|
Vaxjo ID |
248 |
|
Vaccine Adjuvant Name |
Fuc-Sc |
|
Alternative Names |
Fucoidan from sea cucumber Stichopus chloronotus |
|
Adjuvant VO ID |
VO_0005735
|
|
Description |
A sulfated polysaccharide composed mainly of L-fucose and sulfate esters; activates immune cells via TLR2/4–NF-κB pathway |
|
Stage of Development |
Research |
|
Components |
Fucoidan from sea cucumber Stichopus chloronotus (Fuc-Sc) is its main bio-active polysaccharide |
|
Structure |
→3)-α-L-fucose-2S-(1→ linear backbone; sulfated with a 1.0:1.3 L-fucose:sulfate ester ratio |
|
Preparation |
Extracted from sea cucumber using enzymatic digestion and ethanol precipitation Purified by Q-Sepharose and Sephadex G25 chromatography |
|
Dosage |
Tested at 25–400 µg/mL in cell cultures |
|
Function |
Fucoidan from sea cucumber Stichopus chloronotus (Fuc-Sc) is its main bio-active polysaccharide, the immune-activation effects of which have been fully investigated on RAW264.7 cells in the present study. |
|
Safety |
Non-cytotoxic to RAW264.7 cells at tested doses (up to 400 µg/mL) |
| References |
Jiang et al., 2021: Jiang S, Yin H, Li R, Shi W, Mou J, Yang J. The activation effects of fucoidan from sea cucumber Stichopus chloronotus on RAW264.7 cells via TLR2/4-NF-κB pathway and its structure-activity relationship. Carbohydrate polymers. 2021; 270; 118353. [PubMed: 34364600].
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