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rcIL-15 |
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Vaxjo ID |
244 |
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Vaccine Adjuvant Name |
rcIL-15 |
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Alternative Names |
recombinant canine IL-15 |
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Adjuvant VO ID |
VO_0005731
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Description |
A cytokine that promotes proliferation and activation of CD8⺠T cells and NK cells without stimulating Treg cells. Used as an immunostimulatory adjuvant in dogs |
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Stage of Development |
Research |
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Host Species for Testing |
36 |
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Structure |
A recombinant protein (Asn49–Ser162 with His-tag) purified and detoxified |
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Preparation |
Produced and purified with six His-tag residues; administered intravenously at 20 μg/kg/day for 8 days |
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Dosage |
20 μg/kg/day IV for 8 days in beagles |
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Function |
The rcIL-15 injections also stimulated the expression of molecules and transcription factors associated with the activation and effector functions of NK cells, including CD16, NKG2D, NKp30, NKp44, NKp46, perforin, granzyme B, Ly49, T-bet, and Eomes. |
| References |
Lee et al., 2021: Lee SH, Lim YJ, Kim CJ, Yu D, Lee JJ, Won Hong J, Baek YJ, Jung JY, Shin DJ, Kim SK. Safety and immunological effects of recombinant canine IL-15 in dogs. Cytokine. 2021; 148; 155599. [PubMed: 34103211].
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