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IPMPs |
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Vaxjo ID |
226 |
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Vaccine Adjuvant Name |
IPMPs |
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Adjuvant VO ID |
VO_0005637
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Description |
Description: Polymeric microparticles loaded with imiquimod (TLR-7 ligand). |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
PLGA microparticles (PMPs) and imiquimod (TLR-7 ligand)-loaded PLGA microparticles (IPMPs) were prepared by SPG premix membrane emulsification. |
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Structure |
Polymeric microparticles (PLGA) encapsulating imiquimod. |
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Preparation |
Prepared by SPG premix membrane emulsification. |
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Function |
Considering adjuvanticity and safety profiles (PLGA and IMQ, both approved by FDA), we conclude that IMQ-loaded PLGA microparticles are promising robust adjuvant for subunit vaccines |
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Safety |
Considered safe, as PLGA and IMQ components are FDA-approved. |
| References |
Zhang et al., 2015: Zhang W, Wang L, Yang T, Liu Y, Chen X, Liu Q, Jia J, Ma G. Immunopotentiator-Loaded Polymeric Microparticles as Robust Adjuvant to Improve Vaccine Efficacy. Pharmaceutical research. 2015; 32(9); 2837-2850. [PubMed: 26017300].
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