IPMPs |
|
Vaxjo ID |
226 |
|
Vaccine Adjuvant Name |
IPMPs |
|
Adjuvant VO ID |
VO_0005270
|
|
Description |
Description: Polymeric microparticles loaded with imiquimod (TLR-7 ligand). |
|
Stage of Development |
Research |
|
Host Species for Testing |
Mouse |
|
Components |
PLGA microparticles (PMPs) and imiquimod (TLR-7 ligand)-loaded PLGA microparticles (IPMPs) were prepared by SPG premix membrane emulsification. |
|
Structure |
Polymeric microparticles (PLGA) encapsulating imiquimod. |
|
Preparation |
Prepared by SPG premix membrane emulsification. |
|
Function |
Considering adjuvanticity and safety profiles (PLGA and IMQ, both approved by FDA), we conclude that IMQ-loaded PLGA microparticles are promising robust adjuvant for subunit vaccines |
|
Safety |
Considered safe, as PLGA and IMQ components are FDA-approved. |
| Related Vaccine(s) |
|
| References |
Zhang et al., 2015: Zhang W, Wang L, Yang T, Liu Y, Chen X, Liu Q, Jia J, Ma G. Immunopotentiator-Loaded Polymeric Microparticles as Robust Adjuvant to Improve Vaccine Efficacy. Pharmaceutical research. 2015; 32(9); 2837-2850. [PubMed: 26017300].
|
