GITRL |
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Vaxjo ID |
223 |
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Vaccine Adjuvant Name |
GITRL |
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Adjuvant VO ID |
VO_0005270
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Description |
A novel DNA vaccine vector (pIRES/VP1/mGITRL) encoding the enterovirus 71 (EV71) VP1 gene and the mouse glucocorticoid-induced tumor necrosis factor receptor-related protein ligand (mGITRL) gene. It is designed to elicit humoral and cell-mediated immune responses against EV71 VP1. |
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Stage of Development |
Research |
|
Components |
glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and its ligand (GITRL) |
|
Structure |
DNA vaccine vector (pIRES/VP1/mGITRL) encoding the EV71 VP1 gene and the mGITRL gene. |
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Preparation |
A DNA vaccine vector (pIRES/VP1/mGITRL) encoding the EV71 VP1 gene and the mGITRL gene was constructed. |
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Function |
glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and its ligand (GITRL) are involved in modulating both innate and adaptive immune responses |
| Related Vaccine(s) |
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| References |
Yuan et al., 2015: Yuan J, Tang X, Yin K, Tian J, Rui K, Ma J, Mao C, Chen J, Lu L, Xu H, Wang S. GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity. Immunologic research. 2015; 62(1); 81-88. [PubMed: 25772201].
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