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Ribi Vaccine Adjuvant |
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Vaxjo ID |
21 |
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Vaccine Adjuvant Name |
Ribi Vaccine Adjuvant |
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Adjuvant VO ID |
VO_0001238
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Description |
Ribi Adjuvant System (RAS) is a stable oil-in-water emulsion that may be used as an alternative to the water-in-oil emulsions (Sigma Aldrich). |
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Stage of Development |
Research |
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Components |
These adjuvants are derived from bacterial and mycobacterial cell wall components (Sigma Aldrich). |
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Function |
Ribi adjuvant (RA) has been proposed as a suitable alternative, as it stimulates both humoral and cell-mediated immune responses and is non- toxic (Ribi, 1984; Ribi et al., 1986). RA is an oil-in-water emulsion, making it easier to use than Freund's adjuvant (FA), a water-in-oil emulsion (Deeb et al., 1992). |
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Safety |
Ribi Vaccine adjuvants have been prepared to reduce the undesirable side effects of toxicity and allergenicity, but still provide potent stimulus to the immune system (Sigma Aldrich). |
| Related Vaccine(s) |
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| References |
Deeb et al., 1992: Deeb BJ, DiGiacomo RF, Kunz LL, Stewart JL. Comparison of Freund's and Ribi adjuvants for inducing antibodies to the synthetic antigen (TG)-AL in rabbits. Journal of immunological methods. 1992; 152(1); 105-113. [PubMed: 1640105].
Sigma Aldrich: Sigma Aldrich [http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=M6661%7CSIGMA&N25=0&QS=ON&F=SPEC]
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