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SQ

Vaxjo ID 196
Vaccine Adjuvant Name SQ
Adjuvant VO ID VO_0005389
Description squalene oil in water emulsion with QS-21 that induces Th1 response
Stage of Development Research
Location Licensed Switzerland (Vaccine formulation institute)
Host Species for Testing 3
Components squalene and QS-21
Storage 2-8C in the dark
Preparation combine squalene in water emulsion containing cholesterol with QS-21
Function Indirect stimulation via NLRP3 (saponin)
References
(Lawrenz, 2024): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=52]
O'Donnell et al., 2022: O'Donnell JS, Isaacs A, Jakob V, Lebas C, Barnes JB, Reading PC, Young PR, Watterson D, Dubois PM, Collin N, Chappell KJ. Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine. Frontiers in immunology. 2022; 13; 976968. [PubMed: 36119058].
Reinke et al., 2023: Reinke S, Pantazi E, Chappell GR, Sanchez-Martinez A, Guyon R, Fergusson JR, Salman AM, Aktar A, Mukhopadhyay E, Ventura RA, Auderset F, Dubois PM, Collin N, Hill AVS, Bezbradica JS, Milicic A. Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms. Cell reports. Medicine. 2023; 4(11); 101245. [PubMed: 37913775].