S-540956 |
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Vaxjo ID |
190 |
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Vaccine Adjuvant Name |
S-540956 |
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Adjuvant VO ID |
VO_0006104
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|
Description |
oligonucleotide vaccine adjuvant that is a TLR9-agonistic adjuant containing a CpG oligonucleotide annealed to a complementary strand with an amphiphilic chain unit, acts as a potent cancer vaccine adjuvant by targeting draining lymph nodes, induces Th1 response |
|
Stage of Development |
Research |
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Location Licensed |
Japan (Shionogi &Co., Ltd) |
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Host Species for Testing |
Mouse |
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Second Host Species for Testing |
Guinea pig |
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Components |
f B-type CpG ODN2006 (also known as CpG7909), annealed to its complementary sequence oligodeoxynucleotide (ODN) conjugated to a lipid |
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Preparation |
solid-phase synthesis using a typical phosphoramidite method |
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Function |
innate immune activation, induces CD8T cells |
| References |
(Takeuchi, 2024): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=91]
Gill, 1971: Gill DG. The British National Health Service: professional determinants of administrative structure. International journal of health services : planning, administration, evaluation. 1971; 1(4); 342-353. [PubMed: 5003132].
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