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Mast Cell Activator Small Muscles |
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Vaxjo ID |
174 |
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Vaccine Adjuvant Name |
Mast Cell Activator Small Muscles |
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Adjuvant VO ID |
VO_0005381
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Description |
small molecule that induces Th2 response |
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Stage of Development |
Research |
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Location Licensed |
US (Duke University) |
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Host Species for Testing |
3 |
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Components |
Compound 48/80 (C48/80), a cationic polymeric mast cell activating compoun |
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Storage |
lyophilized small molecules stored at 4 C; small molecules reconstituted with DMSO or PEG400 stored at -20 |
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Preparation |
bought from TimTec or made @ Duke; all compounds made in 20-40mM stocks using DMSO solvent in vitro and PEG400 invivo |
| References |
(Staats, 2023): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=54]
Hendy et al., 2023: Hendy DA, Johnson-Weaver BT, Batty CJ, Bachelder EM, Abraham SN, Staats HF, Ainslie KM. Delivery of small molecule mast cell activators for West Nile Virus vaccination using acetalated dextran microparticles. International journal of pharmaceutics. 2023; 634; 122658. [PubMed: 36731641].
Johnson-Weaver et al., 2021: Johnson-Weaver BT, Choi HW, Yang H, Granek JA, Chan C, Abraham SN, Staats HF. Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens. Frontiers in immunology. 2021; 12; 730346. [PubMed: 34566991].
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