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Mannadjuvant

Vaxjo ID 172
Vaccine Adjuvant Name Mannadjuvant
Adjuvant VO ID VO_0005286
Description a carbohydrate, natural compound, combination adjuvant that induces a mixed Th1/Th2 response
Stage of Development Research
Location Licensed US (Boston Children's Hospital)
Host Species for Testing 3
Components fungal mannans
Storage 4C
Preparation various preparations depending on what extracting mannans from
Function Activates Dectin-2-expressing innate immune cells (injection site and draining lymph node)
References
(Zanoni, 2023): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=14]
Borriello et al., 2022: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022; 185(4); 614-629.e21. [PubMed: 35148840].