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Mannadjuvant

Vaxjo ID 172       
Vaccine Adjuvant Name Mannadjuvant       
Adjuvant VO ID VO_0005286
Description a carbohydrate, natural compound, combination adjuvant that induces a mixed Th1/Th2 response       
Stage of Development Research       
Location Licensed US (Boston Children's Hospital)       
Host Species for Testing Mouse       
Components fungal mannans       
Storage 4C       
Preparation various preparations depending on what extracting mannans from       
Function Activates Dectin-2-expressing innate immune cells (injection site and draining lymph node)       
References
(Zanoni, 2023): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=14]
Borriello et al., 2022: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022; 185(4); 614-629.e21. [PubMed: 35148840].