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LTA1 |
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Vaxjo ID |
171 |
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Vaccine Adjuvant Name |
LTA1 |
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Adjuvant VO ID |
VO_0005355
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Description |
A vaccine adjuvant made from the A subunit of heat-labile (LT) enterotoxin of Enterotoxigenic Escherichia coli (ETEC) that is able to induce Th1, Th2, and Th17 immune responses |
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Stage of Development |
Research |
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Location Licensed |
US (Tulane University) |
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Host Species for Testing |
Mouse |
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Components |
isolated enzymatic A1 domain of LT (heat-labile toxin) |
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Storage |
-20C/-80C for long term |
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Preparation |
remove B sub unit from LT |
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Function |
Induces mucosal immunity, Induces epitope spreading, promotes antibody affinity maturation , Promotes antibody epitope spreading |
| References |
(Norton, 2024): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=44]
Norton et al., 2012: Norton EB, Lawson LB, Mahdi Z, Freytag LC, Clements JD. The A subunit of Escherichia coli heat-labile enterotoxin functions as a mucosal adjuvant and promotes IgG2a, IgA, and Th17 responses to vaccine antigens. Infection and immunity. 2012; 80(7); 2426-2435. [PubMed: 22526674].
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