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GLA-AF |
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Vaxjo ID |
160 |
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Vaccine Adjuvant Name |
GLA-AF |
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Adjuvant VO ID |
VO_0005424
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Description |
aqueous formulation (AF) of a chemically synthesized toll-like receptor (TLR) 4 agonist, glucopyranosyl lipid adjuvant (GLA) |
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Stage of Development |
Clinical Trial |
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Location Licensed |
US (AAHI) |
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Host Species for Testing |
Human |
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Second Host Species for Testing |
Mouse |
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Components |
GLA; 100 nM particles and the synthetic surfactant DPPC (dipalmitoylphosphatidylcholine) |
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Storage |
2-8C |
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Preparation |
aqueous formation |
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Function |
innate immune activation |
| References |
(Soza, 2024): Vaccine Adjuvant Compendium - VAC [https://vac.niaid.nih.gov/view?id=66]
Clegg et al., 2014: Clegg CH, Roque R, Perrone LA, Rininger JA, Bowen R, Reed SG. GLA-AF, an emulsion-free vaccine adjuvant for pandemic influenza. PloS one. 2014; 9(2); e88979. [PubMed: 24551202].
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