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Fos47 |
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Vaxjo ID |
158 |
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Vaccine Adjuvant Name |
Fos47 |
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Adjuvant VO ID |
VO_0005291
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Description |
small molecule and Combination adjuvant using tlr4 and tlr7 agonist, induced mixed Th1/Th2 profile |
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Stage of Development |
Research |
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Location Licensed |
US (UCSD) |
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Host Species for Testing |
Mouse |
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Components |
Fos47 comprises small molecule TLR4 (2B182C) and TLR7 (1V270) agonists in a liposomal formulation |
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Storage |
4C, may need sonication after prolonged storage |
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Preparation |
Liposomes were prepared using the thin lipid -film rehydration method and rehydrated with 10 mM sodium phosphate at pH 7.1 with Fos47 |
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Function |
enhanced germinal center reactions in the draining lymph nodes, induced sustained and balanced systemic Th1/Th2 responses, and provided homologous protection from lethal infections |
| References |
(Carson, 2023): Vaccine Adjuvant Compendium (VAC) [https://vac.niaid.nih.gov/view?id=5]
Goff et al., 2017: Goff PH, Hayashi T, He W, Yao S, Cottam HB, Tan GS, Crain B, Krammer F, Messer K, Pu M, Carson DA, Palese P, Corr M. Synthetic Toll-Like Receptor 4 (TLR4) and TLR7 Ligands Work Additively via MyD88 To Induce Protective Antiviral Immunity in Mice. Journal of virology. 2017; 91(19); . [PubMed: 28724768].
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