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Evax-S |
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Vaxjo ID |
157 |
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Vaccine Adjuvant Name |
Evax-S |
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Adjuvant VO ID |
VO_0005511
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Description |
yeast derived squalene oil-in-water emulsion that induces TH1/TH2 response |
|
Stage of Development |
Research |
|
Location Licensed |
US (Evax Inc. Lexington KY) |
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Host Species for Testing |
Mouse |
|
Components |
yeast-derived squalene |
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Storage |
2-8C |
|
Preparation |
introuction into yeast of a squalene synthase-like (SSL) fusion protein of B. braunii SSL-1 and SSL-3 that includes a membrane associating region |
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Function |
Mimic of MF59/Addavax with yeast produced squalene |
| References |
(Kempinski, 2024): Vaccine Adjuvant Compendium (VAC) [https://vac.niaid.nih.gov/view?id=102]
Tateno et al., 2020: Tateno M, Stone BJ, Srodulski SJ, Reedy S, Gawriluk TR, Chambers TM, Woodward J, Chappell J, Kempinski CF. Synthetic Biology-derived triterpenes as efficacious immunomodulating adjuvants. Scientific reports. 2020; 10(1); 17090. [PubMed: 33051497].
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