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CPDI-02 |
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Vaxjo ID |
154 |
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Vaccine Adjuvant Name |
CPDI-02 |
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Adjuvant VO ID |
VO_0006093
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Description |
A vaccine adjuvant that is a peptide which is able to induce Th1/Th2/Th17 immune responses through the mechanism of selectively activates C5aR1 on mononuclear phagocytes vs neutrophils. |
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Stage of Development |
Research |
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Location Licensed |
US (University of Nebraska Medical Center) |
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Host Species for Testing |
Mouse |
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Second Host Species for Testing |
Rat |
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Components |
residue substitutions designed to restrict backbone flexibility in C5a65-74. devoid of c5a like neutrophil and neutropenic activities |
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Storage |
4C w/ desiccation |
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Preparation |
were synthesized by solid-phase methods (https://pmc.ncbi.nlm.nih.gov/articles/PMC2997863/#R19) |
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Function |
induced the release of the pro-inflammatory cytokines IL-6, TNFα, and INFγ from splenic APCs |
| References |
(Vetro, 2023): Vaccine Adjuvant Compendium (VAC) [https://vac.niaid.nih.gov/view?id=40]
Vogen et al., 2001: Vogen SM, Paczkowski NJ, Kirnarsky L, Short A, Whitmore JB, Sherman SA, Taylor SM, Sanderson SD. Differential activities of decapeptide agonists of human C5a: the conformational effects of backbone N-methylation. International immunopharmacology. 2001; 1(12); 2151-2162. [PubMed: 11710544].
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