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CAF-01 |
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Vaxjo ID |
151 |
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Vaccine Adjuvant Name |
CAF-01 |
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Adjuvant VO ID |
VO_0005483
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Description |
A vaccine adjuvant is a gadoteridol-loaded cationic adjuvant formulation 01 that induced a Th1/Th17 type of immune response |
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Stage of Development |
Clinical Trial |
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Location Licensed |
Denmark |
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Components |
cationic liposomes based on the surfactant dimethyldioctadecylammonium (DDA) bromide and the glycolipid trehalose-6,6’-dibehenate (TDB) |
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Preparation |
liposomes prepared using thin film method |
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Function |
Type: liposome-based vaccine adjuvant. Target receptor: C-type lectin domain family 4 member E (Mincle). Induces Th1/Th17 mixed immune profile. antigen and activates DCs, induces both humoral and cell-mediated memory immune response, Enhances germinal center responses. |
| References |
Kloverpris et al., 2009: Kloverpris H, Karlsson I, Bonde J, Thorn M, Vinner L, Pedersen AE, Hentze JL, Andresen BS, Svane IM, Gerstoft J, Kronborg G, Fomsgaard A. Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes. AIDS (London, England). 2009; 23(11); 1329-1340. [PubMed: 19528789].
Semmes et al., 2020: Semmes EC, Chen JL, Goswami R, Burt TD, Permar SR, Fouda GG. Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health. Frontiers in immunology. 2020; 11; 595297. [PubMed: 33552052].
Thakur et al., 2020: Thakur A, Pinto FE, Hansen HS, Andersen P, Christensen D, Janfelt C, Foged C. Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone. Frontiers in immunology. 2020; 11; 803. [PubMed: 32457748].
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