|
|
BI-Eng2+Adjuplex |
|
Vaxjo ID |
150 |
|
Vaccine Adjuvant Name |
BI-Eng2+Adjuplex |
|
Adjuvant VO ID |
VO_0005508
|
|
Description |
Combination vaccine adjuvant contains both Bl-Eng2 and adjuplex vaccine adjuvants and is able to induce a mixed Th1/Th2 response |
|
Stage of Development |
Research |
|
Location Licensed |
US (University of Wisconsin) |
|
Host Species for Testing |
3 |
|
Components |
glycoprotein |
|
Function |
induces the production of IL-1β and IL-6 by dendritic cells and acts as an adjuvant to promote differentiation of CD4+ T cells into anti-fungal Th17 cells |
| References |
Dos et al., 2021: Dos Santos Dias L, Dobson HE, Bakke BK, Kujoth GC, Huang J, Kohn EM, Taira CL, Wang H, Supekar NT, Fites JS, Gates D, Gomez CL, Specht CA, Levitz SM, Azadi P, Li L, Suresh M, Klein BS, Wüthrich M. Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity. PLoS pathogens. 2021; 17(3); e1009324. [PubMed: 33735218].
VAC- Bl-Eng2+Adjuplex: [https://vac.niaid.nih.gov/view?id=98]
|
|
