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BECC470b |
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Vaxjo ID |
125 |
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Vaccine Adjuvant Name |
BECC470b |
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Adjuvant VO ID |
VO_0005296
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Description |
small molecule with TLR4 receptor that induces Th1/Th2 response |
|
Stage of Development |
Research |
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Location Licensed |
US (University of Maryland, Baltimore) |
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Host Species for Testing |
Mouse |
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Function |
Type: TLR agonist vaccine adjuvant. Target Receptor: Toll-like receptor 4. Induces Th1/Th2 mixed immune profile. TLR agonist |
| References |
(Ernst, 2021): Vaccine Adjuvant Compendium (VAC) [https://vac.niaid.nih.gov/view?id=32]
Gregg et al., 2017: Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK. Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery. mBio. 2017; 8(3); . [PubMed: 28487429].
Hu et al., 2023: Hu G, Varisco DJ, Das S, Middaugh CR, Gardner F, Ernst RK, Picking WL, Picking WD. Physicochemical characterization of biological and synthetic forms of two lipid A-based TLR4 agonists. Heliyon. 2023; 9(7); e18119. [PubMed: 37483830].
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