VIOLIN: Vaccine Investigation and Online Information Network

Tarp

General Information

Protegen ID

872

Sequence Strain (Species/Organism)

Chlamydia muridarum str. Nigg

Taxonomy ID

243161

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization of mice with Tarp induced Th1-dominant immunity that significantly reduced the shedding of live organisms from the lower genital tract and attenuated inflammatory pathologies in the fallopian tube tissues. Tarp, an immunodominant antigen identified by human antisera, can induce protective immunity against chlamydial infection and pathology in mice (Wang et al., 2009).

Related Vaccines(s)

C. muridarum Tarp subunit vaccine

References

Wang et al., 2009: Wang J, Chen L, Chen F, Zhang X, Zhang Y, Baseman J, Perdue S, Yeh IT, Shain R, Holland M, Bailey R, Mabey D, Yu P, Zhong G. A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice. Vaccine. 2009; 27(22); 2967-2980. [PubMed: 19428908].

Gene Information

Gene Name

Tarp

NCBI Gene ID

1245826

Genbank Accession

AE002160

Locus Tag

TC_RS02355

Gene Starting Position

571045

Gene Ending Position

572607

DNA Sequence

>NC_002620.2:571045-572607 Chlamydia muridarum Nigg, complete genome
CATGCGCAAGGTATCAGTGGGAATCTGCTTGCTTATCGCATTAGCAACAGCAATTACCGGCTGCTCCAAA
TCCTCCTCAAACAAATCAAATCACTCCTCCTCTAATCAAAGCGTATCTGTGAGCATGAAGGACGATCCTC
GCACGTTTGACCCTCGAGAGGTTAGGCTTCTTTCGGATATTAATTTGATTCACCATCTTTATGAGGGACT
GGTTCAAGAGACTCCTTCCGGAGAGGTTTTCCCTGCATTAGCAGAAAGTTTCTTCCTATCTGAAGATAAG
AAAACCTACACTTTCCACCTAAAAAAAGCACTCTGGAGTAATGGAGACCTGATTACTGCTCATGATTTTG
TACGTTCTTGGAACGATGTTTTGCAAAATCGCATTGCAAGTATCTACTCTTTCGCTTTTTTACCCATTGA
TTTAAGTAAAGATTGTGGATTCTTCGCTAAGGACAATCATACACTTGTTATCAATTTGCATACCCCTACT
CCACACTTTCTGAAATTACTTACCCTTCCAGTATTTTATCCTGTGCACCCCGAACATCAAATTCGGAATG
AAGCAAAAGCTCTTCCAATATCTACAGGGGCTTTTTGTTTAAAAGAGAAAAAAGATCGGCGGTGGCTTAA
ATTAGAAAAAAATCCCTATTATTATAACAAAGAGCAAGTTGCGATCCAGGAAATCCACATACATGTGATT
CCTGATCAGCAGACCGCTTCTGCTTTGTTCAAACAAGGAAAATTGGATTGGCAAGGACTTCCTTGGGGAC
ACAGCATTCCCCAAGAAGCTTTAGCAACAGCAAATAAACGTCGTACTCCTCAATCATTTGATATATCTGG
CACCTCGTGGCTCACGTTCAACACATCAAAAGTACCCTTCAGCCATCCCAAGTTGCGACAAGCTTTAAGC
CTTGTTCTAAATAAGGAAGCCTTAGCCTCTCCAACCTTTGTTAAGCCCGCTAAACACCTACTTCCTACAC
ACCTGCACACTTATCCAGAGCAACCTACTTACAAACAACAAGAAGCCGTCATTTTAGCCAAAACTCTGTT
ACAAGAAGCATTAACAGATCTTAATATGACTATAAAAGATCTTGAAAAATGCCCTTTGATTTTTTCAGCG
ACATCTAGCGTCAACTCACAAATGGCCCAAATGATGCGCGATCAATGGCGAAGAATTTTAGGAATAACAT
TCCCTATTTGCGGGAAAGAGTATGCTTTATTACAAAATGATTTGACCACCAACACTTTTTTTATGTCCAT
AAACGGTTGGTTTGCAGACTTTTCCGATCCTTTAGCCTTCTTGTCTGTTTTTTCTTCTAAGGGAATCAAA
CCTTATGCCTTACAAGACCCTCTGTTTGACCAGCTTATTCTCTCTATAGAAACGGAAAAAGATCCTCGAA
AGCGTATTTCTCTGATTTCCGAAGCTTCTCTATACCTAGAAAAACAAAATATCATAGAACCGCTCTATCA
CGATGTTTTTCACTATGCCGCAAATAATAAACTTTCTTTTGTTAGATTACATCCCTCAGGTCTTGTCGAT
ATGCGGTATGCAAAAAACTCTTG

Protein Information

Protein Name

peptide ABC transporter substrate-binding protein

NCBI Protein GI

497916366

Protein Accession

WP_010230522

Protein pI

9.01

Protein Weight

56833.03

Protein Length

520

Protein Note

similar to GB:D00760, SP:P25787, and PID:220024; identified by sequence similarity; putative

Protein Sequence

>WP_010230522.1 peptide ABC transporter substrate-binding protein [Chlamydia muridarum]
MRKVSVGICLLIALATAITGCSKSSSNKSNHSSSNQSVSVSMKDDPRTFDPREVRLLSDINLIHHLYEGL
VQETPSGEVFPALAESFFLSEDKKTYTFHLKKALWSNGDLITAHDFVRSWNDVLQNRIASIYSFAFLPID
LSKDCGFFAKDNHTLVINLHTPTPHFLKLLTLPVFYPVHPEHQIRNEAKALPISTGAFCLKEKKDRRWLK
LEKNPYYYNKEQVAIQEIHIHVIPDQQTASALFKQGKLDWQGLPWGHSIPQEALATANKRRTPQSFDISG
TSWLTFNTSKVPFSHPKLRQALSLVLNKEALASPTFVKPAKHLLPTHLHTYPEQPTYKQQEAVILAKTLL
QEALTDLNMTIKDLEKCPLIFSATSSVNSQMAQMMRDQWRRILGITFPICGKEYALLQNDLTTNTFFMSI
NGWFADFSDPLAFLSVFSSKGIKPYALQDPLFDQLILSIETEKDPRKRISLISEASLYLEKQNIIEPLYH
DVFHYAANNKLSFVRLHPSGLVDMRYAKNS

Epitope Information

IEDB Linear Epitope