VIOLIN: Vaccine Investigation and Online Information Network

HAP

General Information

Protegen ID

871

Sequence Strain (Species/Organism)

Streptococcus equi subsp. equi 4047

Taxonomy ID

553482

Other Database IDs

CDD:226636
CDD:173869

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization with HAP-GST significantly reduced rhinitis in Balb/C mice challenged nasally with S. equi and significantly increased survival time and clearance of bacteria in CBA/CA mice challenged intraperitoneally with S. zooepidemicus (Chanter et al., 1999).

References

Chanter et al., 1999: Chanter N, Ward CL, Talbot NC, Flanagan JA, Binns M, Houghton SB, Smith KC, Mumford JA. Recombinant hyaluronate associated protein as a protective immunogen against Streptococcus equi and Streptococcus zooepidemicus challenge in mice. Microbial pathogenesis. 1999; 27(3); 133-143. [PubMed: 10455004].

Gene Information

Gene Name

HAP

Protein Information

Protein Name

hyaluronate-associated protein precursor

NCBI Protein GI

4336671

Protein pI

5.08

Protein Weight

53754.78

Protein Length

622

Protein Note

ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; COG4166

Protein Sequence

>AAD17886.1 hyaluronate-associated protein precursor [Streptococcus equi subsp. equi 4047]
MTVLGTKACKRLGLAAVTLASVAALMACGNKQSASTDKKSEINWYTPTEIITLDISKNTDTYSALAIGNS
GSNLLRADAKGKLQPDLAEKVDVSEDGLTYTATLRDGLKWSDGSDLTAEDFVYSWQRMVDPKTASEYAYL
ATESHLKNAEDINSGKNPDLDSLGVKADGNKVIFTLTEPAPQFKSLLSFSNFVPQKESFVKDAGKDYGTT
SEKQIYSGPYIVKDWNGTSGTFKLVKNKNYWDAKNVKTETVNVQTVKKPDTAVQMYKQGKLDFANISGTS
AIYNANKKHKDVVPVLEATTAYIVYNQTGAIEGLNSLKIRQALNLATDRKGIVSAAVDTGSKPATALVPT
GLAKLSDGTDLTEHVAPGYKYDDKEAAKLFKEGLAELGKDALTITITADADAPAAKSAVDYIKETWETAL
PGLTVEEKFVPFKQRLEDTKNQNFEVAVVLWGGDYPKGSTFYGLFKSGSAYNYGKFTNADYDAAYNKALT
TDALNTDAAADDYKAAEKALYDNALYNPLYLP

Epitope Information

IEDB Linear Epitope