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Gp46

General Information
Protegen ID 755
Sequence Strain (Species/Organism) Leishmania amazonensis
VO ID VO_0011292
Taxonomy ID 5659
Other Database IDs CDD:178695
CDD:275380
Molecule Role Protective antigen
Molecule Role Annotation cDNAs encoding L. m. amazonensis gp46 antigen were subcloned into the VR1012 plasmid, and susceptible BALB/c mice were immunised with two i.m. injections of 100 microg of plasmid DNA. Mice were challenged by the injection of 4 x 10^6 L. m. mexicana parasites in the foot pad to evaluate protection. Measurement of lesion size indicated that mice immunised with VR012-GP46 were partially protected against infection (Dumonteil et al., 2000).
Related Vaccines(s) L. amazonensis DNA vaccine encoding GP46
References
Dumonteil et al., 2000: Dumonteil E, Andrade-Narvarez F, Escobedo-Ortegon J, Ramirez-Sierra MJ, Valencia-Pacheco G, Flores-Serrano A, Canto-Lara S, Arjona-Torres A. Comparative study of DNA vaccines encoding various antigens against Leishmania mexicana. Developments in biologicals. 2000; 104; 135-141. [PubMed: 11713811].
Gene Information
Gene Name Gp46
NCBI Nucleotide GI 159320
DNA Sequence 
>gi|159320|gb|M38368.1|LEIGP46M2 L.amazonensis surface membrane glycoprotein GP46/M-2 gene, complete cds
ATGGCGCAGTGCGTGCGTCGGCTGGTGCTGGCGGCGCCCCTCGCCGCTGTGGTGGCGCTGCTGCTGTGCA
CGAGCAGTGCACCGGTGGCGCGTGCTGCGGGGACGAGCGACTTCACTGGTGCGCAGCAGAAGAACACGCT
GACGGTGCTGCAGGCGTTTGCGCGTGCGATCCCTGCGCTTGGGGACACGTGGACGGGCAGCGACTTCTGC
TCGTGGGAGCACATCATCTGCTACTCCTCCGGCGTCGGCGTGTGGATGCACAATGTGGATTATACCGGCA
CGCTGCCGGAGATGCCTGCGAGCGTCGACTACAAGGACGTCATGATCTTGGCACTGGACTTCGGCGCAAT
GGGCCAGGGGCTGAGCGGGACGCTGCCCCCCTCATGGAGCTCGATGAAGCACCTGATCGTTCTGGATCTG
GAGGGCACTAAGGTGTCCGGCACGCTGCCGCCCGAGTGGAGTGAGATGACGAGTGCTGAGGCCCTGCAGC
TGGAGAACTGCGGTCTGTCCGGGAGTCTGCCCACCTCGTGGTCTTCGATGCCGAAGCTGCGTATCGTCTC
ACTGAGCGGCAACCACTTCTGCGGGTGCGTGCCCGACTCGTGGAGGGAGAAGGACCGCCTCGATGTGACC
ATCGAGGAATGGCACATGGGCGAGGACTGCAAGCTTGCTAACGCCTGCCGCCCGACTGCTGCTCCGGGAA
CGACCACGACTAACCCGCCCACCACCACCGGCACCCCAGCAGCCTCCTCTACTCCTTCTCCAGGGTCGGG
GTGCGAGGTGGATGGGTGTGAGGTGTGCGAGGGGGACTCCGCTGCGCGGTGCGCCAGGTGCCGTGAGGGC
TACTCCCTGACGGACGAGAAGACGTGCCTGGGCGAACCACGATGGCGGCGTGGCGGCGGCGTCGAGCGGA
CGGCTGGCTGCCGCTGCTGTGTGGGCGGCTGTGCTGTTGAGCGTGGGGCTGGTGGCGTGAGGGTGCGGCG
GGCCCCTCTTCTCTGTGGTGCCCCTGGTGCCTGCCCTCGCCCCCGGCACGGCGTCGTCGCTGCCCTCTCA
CCCCCACCAGCCGACGGGGAGACCGACAGCCACACGCGCACGCGCACACGCCGTCGTGCATCGCGTGTGC
TTTCCGCCGTTGTGGCGCCTGCGCGGATGCACGGGCATGCGGAGGCGTGCATGCGTGTGCGCGTGCCGGC
TCTTGTGTGTCTCTCCGTGTGGCCAGCAGTCGGCACCCGCCGCCGATCGAATGTGCGCGCGGCGGCGGTG
TGTCGCCTTGGACAGCGGAGATGCGGCGCCCGCCCCTCGCCGTGTGCCTCGGTCTGCGTGTCGTGGCCGC
GCGAGCGACGTACGGAGTGCGCGTGTCCGGCCCTCTTCGACGGGGCTCGCTTGCGGTGCTGTGCTCTCGT
GGTCTGTGCCGGTGCTGCCCCGGCGGGGTGA
Protein Information
Protein Name surface membrane glycoprotein GP46/M-2
NCBI Protein GI 159321
Protein Accession AAA29234.1
Protein pI 8.21
Protein Weight 46877.99
Protein Length 560
Protein Note hypothetical protein; Provisional
Protein Sequence 
>AAA29234.1 surface membrane glycoprotein GP46/M-2 [Leishmania amazonensis]
MAQCVRRLVLAAPLAAVVALLLCTSSAPVARAAGTSDFTGAQQKNTLTVLQAFARAIPALGDTWTGSDFC
SWEHIICYSSGVGVWMHNVDYTGTLPEMPASVDYKDVMILALDFGAMGQGLSGTLPPSWSSMKHLIVLDL
EGTKVSGTLPPEWSEMTSAEALQLENCGLSGSLPTSWSSMPKLRIVSLSGNHFCGCVPDSWREKDRLDVT
IEEWHMGEDCKLANACRPTAAPGTTTTNPPTTTGTPAASSTPSPGSGCEVDGCEVCEGDSAARCARCREG
YSLTDEKTCLGEPRWRRGGGVERTAGCRCCVGGCAVERGAGGVRVRRAPLLCGAPGACPRPRHGVVAALS
PPPADGETDSHTRTRTRRRASRVLSAVVAPARMHGHAEACMRVRVPALVCLSVWPAVGTRRRSNVRAAAV
CRLGQRRCGARPSPCASVCVSWPRERRTECACPALFDGARLRCCALVVCAGAAPAG
Epitope Information
IEDB Linear Epitope