VIOLIN: Vaccine Investigation and Online Information Network

HASPB1

General Information

Protegen ID

749

Sequence Strain (Species/Organism)

Leishmania infantum

VO ID

VO_0011286

Taxonomy ID

5661

Other Database IDs

CDD:273344
UniProtKB/TrEMBL: O77301

Molecule Role

Protective antigen

Molecule Role Annotation

Following infection with L. infantum promastigotes, four out of eight beagle dogs immunized with HASPB1 Montanide remained free of clinical signs, compared to two out of eight dogs in the control group. The results demonstrate that HASPB1 antigens with Montanide were able to induce partial protection against canine leishmaniasis, even under extreme experimental challenge conditions (Moreno et al., 2007).

Related Vaccines(s)

L. infantum HASPB1 protein vaccine

References

Moreno et al., 2007: Moreno J, Nieto J, Masina S, CaÃ±avate C, Cruz I, Chicharro C, Carrillo E, Napp S, Reymond C, Kaye PM, Smith DF, Fasel N, Alvar J. Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis. Vaccine. 2007; 25(29); 5290-5300. [PubMed: 17576026].

Gene Information

Gene Name

HASPB1

NCBI Gene ID

5069221

NCBI Nucleotide GI

3724133

DNA Sequence

>gi|3724133|emb|AJ011810.1| Leishmania donovani HASPB1 gene
ATGGGAACTTCTTGTACAAAGGACTCCGCAAAGGAGCCCCAGAAGCGTGCTGATAACATCCATAAAACCA
CTGAGGCCAATCACGGAGGCGCCACTGGTGTGCCCCCGAAGCACACCGGCAGTGCGATGAACGACTCTGC
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCTAAGGAGGACG
GCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGG
CCCTAAGGAGGACGGCCATACACAGAAAAATGACGGCGATGGCCCGAAGGAGGACGGCCATACACAGAAA
AATGACGGCGATGGCCCTAAGGAGGGTGAGAATCTGCAGCAAAACGATGGGGATGCGCAGGAGAAGAACG
AAGATGGACACAACGTGGGGGATGGAGCTAACGGCAATGAGGATGGTAACGATGATCAGCCGAAGGAGCA
CGCTGCCGGCAACTAG

Protein Information

Protein Name

HASPB1 protein

NCBI Protein GI

3724134

Protein Accession

CAA09789.1

Protein pI

4.47

Protein Weight

42746.61

Protein Length

457

Protein Note

K+-dependent Na+/Ca+ exchanger; TIGR00927

Protein Sequence

>CAA09789.1 HASPB1 protein [Leishmania donovani]
MGTSCTKDSAKEPQKRADNIHKTTEANHGGATGVPPKHTGSAMNDSAPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQKNDGDGPKEDGHTQK
NDGDGPKEGENLQQNDGDAQEKNEDGHNVGDGANGNEDGNDDQPKEHAAGN

Epitope Information

IEDB Linear Epitope