VIOLIN: Vaccine Investigation and Online Information Network

P36/LACK

General Information

Protegen ID

747

Sequence Strain (Species/Organism)

Leishmania infantum

VO ID

VO_0011284

Taxonomy ID

5671

Other Database IDs

CDD:238121
CDD:293791
InterPro: IPR001680
InterPro: IPR011046
InterPro: IPR015943
InterPro: IPR017986
InterPro: IPR019775
InterPro: IPR019781
InterPro: IPR019782
InterPro: IPR020472
UniProtKB/UniProt: P62884

Molecule Role

Protective antigen

Molecule Role Annotation

BALB/c mice immunized with a DNA vector expressing p36/LACK of Leishmania infantum followed by a booster with VVp36/LACK induced significant protection against Leishmania major infection (Gonzalo et al., 2001).

Related Vaccines(s)

VVr expressing L. infantum P36/LACK

References

Gonzalo et al., 2001: Gonzalo RM, RodrÃguez JR, RodrÃguez D, GonzÃ¡lez-Aseguinolaza G, Larraga V, Esteban M. Protective immune response against cutaneous leishmaniasis by prime/booster immunization regimens with vaccinia virus recombinants expressing Leishmania infantum p36/LACK and IL-12 in combination with purified p36. Microbes and infection / Institut Pasteur. 2001; 3(9); 701-711. [PubMed: 11489418].

Gene Information

Gene Name

P36/LACK

Protein Information

Protein Name

activated protein kinase c receptor (LACK); p36 LACK protein

NCBI Protein GI

134085114

Protein pI

6.77

Protein Weight

33141.22

Protein Length

413

Protein Note

guanine nucleotide-binding protein beta subunit-like protein

Protein Sequence

>CAM69515.1 activated protein kinase c receptor (LACK); p36 LACK protein [Leishmania infantum]
MNYEGHLKGHRGWVTSLACPQQAGSYIKVVSTSRDGTAISWKANPDRHSVDSDYGLPSHRLEGHTGFVSC
VSLAHATDYALTASWDRSIRMWDLRNGQCQRKFLKHTKDVLAVAFSPDDRLIVSAGRDNVIRVWNVAGEC
MHEFLRDGHEDWVSSICFSPSLEHPIVVSGSWDNTIKVWNVNGGKCERTLKGHSNYVSTVTVSPDGSLCA
SGGKDGAALLWDLSTGEQLFKINVESPINQIAFSPNRFWMCVATERSLSVYDLESKAVIAELTPDGAKPS
ECISIAWSADGNTLYSGHKDNLIRVWSISDAE

Epitope Information

IEDB Linear Epitope