VIOLIN: Vaccine Investigation and Online Information Network

FCR3S1.2-var1

General Information

Protegen ID

645

Sequence Strain (Species/Organism)

Plasmodium falciparum

VO ID

VO_0011229

Taxonomy ID

5833

Other Database IDs

CDD:292087
CDD:283158
CDD:281064
CDD:114603
CDD:292085

Molecule Role

Protective antigen

Molecule Role Annotation

Immunized animals were challenged in vivo with various parasite strains or clones of malaria. Immunization with the PfEMP1-DBL1 alpha domain abolished the PfEMP1-dependent sequestration of the homologous strain in immunized rats and substantially inhibited parasite adhesion in immunized monkeys. Protection against sequestration of heterologous parasite strains was also confirmed by direct or indirect challenge in the rat model (Moll et al., 2007).

References

Moll et al., 2007: Moll K, Pettersson F, Vogt AM, Jonsson C, Rasti N, Ahuja S, SpÃ¥ngberg M, Mercereau-Puijalon O, Arnot DE, Wahlgren M, Chen Q. Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domain. Infection and immunity. 2007; 75(1); 211-219. [PubMed: 17074852].

Gene Information

Gene Name

FCR3S1.2-var1

NCBI Gene ID

810160

Protein Information

Protein Name

erythrocyte membrane protein 1

NCBI Protein GI

2961468

Protein pI

5.45

Protein Weight

244016.11

Protein Length

2328

Protein Note

N-terminal segments of PfEMP1; pfam15447

Protein Sequence

>AAC05730.1 erythrocyte membrane protein 1 [Plasmodium falciparum]
MATSGGSGGTQDEDAKHVLDEFGQKVHDEVHGEAKNYVSELKGSLSLASILGETAFTVKSMQTESKYTEL
IEANSKRNPCKKDGKGNDVDRFSVKEQAGYDNKKMKCSNGMTCAPFRRLHLCNKNFPNMNSNDSSKAKHD
LLAEVCMAAKYEGESIKTHYPKYDSKYPGSDFPMCTMLARSFADIGDIIRGRDLYLGNKKKKQNGKETER
EKLEQKLKEIFKKIHDNLKDKEAQKRYNGDEDPNFYKLREDWWTANRETVWGAMTCSKELDNSSYFRATC
NDTGQGPSQTHNKCRCDKDKGANAGKPKAGDGDVTIVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLENLE
KQCRGKDKSDEYRYCSRNGYDCEQTISRKGKVRMGKGCTDCFFACHSYENWIDNQRKQFDKQKKYTKEIS
DGGGRKKRAVGGTTKYEGYEKSFYEKLKNDGYGTVDAFLGLLNNEKACKDITDGGKINFKEVNSGGGVVG
GGSGGTSGASGTNDENKGTFYRSEYCQPCPDCGVQHKGGNQWERKTKVKKMRWSKLYKPINGKMVLLLKS
LKVVKDMMILKKNWKEFCLTQNSSDGSVGSVVTTGASGGNSEKKELYDEWKCYKHNEVQKVNVQGEVEED
DDELKGAGGLCILPNPKKNKEVSEAKSQNNHADIQKTFHDFFYYWVAHMLKDSIHWRTKRLKSCISDGKT
MKCRNGCNKKCDCFEKWVKQKETEWKPIKDHFKTQEGIPEGYYFTTLELILKLQFLKEDTEENTENSLDA
EEAEELKHLQKILKLENENNLAVVNAGTEQKTLMDKLLNHELNDATKCKDCPLPEEDKSRGRSADPSPDI
FIPRPEEKEDDENEDDDEDEVRDDEETAKETTEGSATDTTTSLDVCPIVGKVLTKDNESLQDACSLKYGG
NNSRLGWRCVTPSGEPTTSSDKNGAICVPPRRRRLYIKKIVDWATKTESPQASGSEASSTSGSTTPPDSK
EALLKAFVESAAIETFFLWHRYKEEKKAVAQEGAGHGLPRVEEGSPEYDPEDKLKEGKIPDGFLRQMFYT
LGDYRDILFSGSNDTTSVSKDTPSSSNDNLKNIVLLASGSTEQEREKMNKYKEIKNFRKCSTERSAPNLV
SHPQTWWENNGKYIWHGMVCALTSKDKIAKGVEKKPQKIENPENLWDEANKKPKPPQYQYTNVKLDENSG
TSPRTTQTQASSDNTPTTLTHFVKRPTYFRWFEEWGESFCRERKKRLKQIKVDCKVENGDVGRCSGDGEA
CDSISTHDYSTVPSFNCPGCGKHCSSYRKWIERKKIEFHKQSNAYGQQKTDATRNNGNTFDKEFCKTLET
WPDAAKFLERLKNGPCKTNKEYGGDDIDFEKDSKTFQHTEYCGPCPKFKTNCQNGNCGVSGLNGNCDGKD
SIDAKEIAKMRSSTTDVVMRVSDNDTNTFEGDDLKDACQHANIFKGIRKDVWKCGYVCGVDICEQTNINE
RTDGKEYIQIRALFKRWVENFLEDYNKINDKISHCIKKGEGSKCINGCEKNSKCLEKWIEKKIAEWENIK
KRFNDQYENKDQPDYNVKSILEELIPKIAVVNDQDNVIKLCVFENSKGCTLISNTQNNKENDAIDCMLKK
LGVKAKNCPGKPSGEKQSDCKEPPPLPDEEDQNPEENTLEPPKFCPPTTQPPEEKGGETCGNKEEKKDEK
KEESEEPAKEESGPAAEEPAPTAESEETETNFPEPPGTGPAAPPSTPAPPTPDTPPPLRPQADEPFDSTI
LQTTIPFGVALALGSIAFLFLKKKTKASVGNLFQILQIPKSDYDIPTLKSSNRYIPYVSDRYKGKTYIYM
EGDSDEDKYAFMSDTTDVTSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTRND
IQNDGIPSSKITDNEWNQLKKEFISNMLQNQPNDVPNDYTSGNSSTNTNITTTSRHNVDNNTNTTMSRDN
MEENLLLPSIHDRNLYSGEEYSYNVNMVNSMNDIPINRDNNVYSGIDLINDSLSGGKPIDIYDEVLKRKE
NELFGTENTKRTSTQNVAKITNSDPIHNQLELFHKWLDRHRDMCEKWKNKEDILNKLKEEWNKENINNSG
KTYNSDNKPSHNHVLNTDVSIQIDMDNPKTKNEITNMDTNQDKSTMDTILDDLEKYNDPYYYDFYEDDII
YHDVDVEKSSMDDIYVDHNNVTSNNMDVPTKMHIEMNIVNNKKEIFEEEYPISDIWNI

Epitope Information

IEDB Linear Epitope

MATSGGSGGTQDEDAKHVLDEFGQKVHDEVHGEAKNYVSELKGSLSLASILGETAFTVKSMQTESKYTELIEANSKRNPCKKDGKGNDVDRFSVKEQAGYDNKKMKCSNGMTCAPFRRLHLCNKNFPNMNSNDSSKAKHDLLAEVCMAAKYEGESIKTHYPKYDSKYPGSDFPMCTMLARSFADIGDIIRGRDLYLGNKKKKQNGKETEREKLEQKLKEIFKKIHDNLKDKEAQKRYNGDEDPNFYKLREDWWTANRETVWGAMTCSKELDNSSYFRATCNDTGQGPSQTHNKCRCDKDKGANAGKPKAGDGDVTIVPTYFDYVPQYLRWFEEWAEDFCRKKKKKLENLEKQCRGKDKSDEYRYCSRNGYDCEQTISRKGKVRMGKGCTDCFFACHSYENWIDNQRKQFDKQKKYTKEISDGGGRKKRAVGGTTKYEGYEKSFYEKLKNDGYGTVDAFLGLLNNEKACKDITDGGKINFKEVNSGGGVVGGGSGGTSGASGTNDENKGTFYRSEYCQPCPDCGVQHKGGNQWERKTKVKKMRWSKLYKPINGKMVLLLKSLKVVKDMMILKKNWKEFCLTQNSSDGSVGSVVTTGASGGNSEKKELYDEWKCYKHNEVQKVNVQGEVEEDDDELKGAGGLCILPNPKKNKEVSEAKSQNNHADIQKTFHDFFYYWVAHMLKDSIHWRTKRLKSCISDGKTMKCRNGCNKKCDCFEKWVKQKETEWKPIKDHFKTQEGIPEGYYFTTLELILKLQFLKEDTEENTENSLDAEEAEELKHLQKILKLENENNLAVVNAGTEQKTLMDKLLNHELNDATKCKDCPLPEEDKSRGRSADPSPDIFIPRPEEKEDDENEDDDEDEVRDDEETAKETTEGSATDTTTSLDVCPIVGKVLTKDNESLQDACSLKYGGNNSRLGWRCVTPSGEPTTSSDKNGAICVPPRRRRLYIKKIVDWATKTESPQASGSEASSTSGSTTPPDSKEALLKAFVESAAIETFFLWHRYKEEKKAVAQEGAGHGLPRVEEGSPEYDPEDKLKEGKIPDGFLRQMFYTLGDYRDILFSGSNDTTSVSKDTPSSSNDNLKNIVLLASGSTEQEREKMNKYKEIKNFRKCSTERSAPNLVSHPQTWWENNGKYIWHGMVCALTSKDKIAKGVEKKPQKIENPENLWDEANKKPKPPQYQYTNVKLDENSGTSPRTTQTQASSDNTPTTLTHFVKRPTYFRWFEEWGESFCRERKKRLKQIKVDCKVENGDVGRCSGDGEACDSISTHDYSTVPSFNCPGCGKHCSSYRKWIERKKIEFHKQSNAYGQQKTDATRNNGNTFDKEFCKTLETWPDAAKFLERLKNGPCKTNKEYGGDDIDFEKDSKTFQHTEYCGPCPKFKTNCQNGNCGVSGLNGNCDGKDSIDAKEIAKMRSSTTDVVMRVSDNDTNTFEGDDLKDACQHANIFKGIRKDVWKCGYVCGVDICEQTNINERTDGKEYIQIRALFKRWVENFLEDYNKINDKISHCIKKGEGSKCINGCEKNSKCLEKWIEKKIAEWENIKKRFNDQYENKDQPDYNVKSILEELIPKIAVVNDQDNVIKLCVFENSKGCTLISNTQNNKENDAIDCMLKKLGVKAKNCPGKPSGEKQSDCKEPPPLPDEEDQNPEENTLEPPKFCPPTTQPPEEKGGETCGNKEEKKDEKKEESEEPAKEESGPAAEEPAPTAESEETETNFPEPPGTGPAAPPSTPAPPTPDTPPPLRPQADEPFDSTILQTTIPFGVALALGSIAFLFLKKKTKASVGNLFQILQIPKSDYDIPTLKSSNRYIPYVSDRYKGKTYIYMEGDSDEDKYAFMSDTTDVTSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSGNNTTASGKNTPSDTRNDIQNDGIPSSKITDNEWNQLKKEFISNMLQNQPNDVPNDYTSGNSSTNTNITTTSRHNVDNNTNTTMSRDNMEENLLLPSIHDRNLYSGEEYSYNVNMVNSMNDIPINRDNNVYSGIDLINDSLSGGKPIDIYDEVLKRKENELFGTENTKRTSTQNVAKITNSDPIHNQLELFHKWLDRHRDMCEKWKNKEDILNKLKEEWNKENINNSGKTYNSDNKPSHNHVLNTDVSIQIDMDNPKTKNEITNMDTNQDKSTMDTILDDLEKYNDPYYYDFYEDDIIYHDVDVEKSSMDDIYVDHNNVTSNNMDVPTKMHIEMNIVNNKKEIFEEEYPISDIWNI