VIOLIN: Vaccine Investigation and Online Information Network

TA17050 merozoite-piroplasm surface antigen Tams1

General Information

Protegen ID

603

Sequence Strain (Species/Organism)

Theileria annulata

VO ID

VO_0011188

Taxonomy ID

5874

Molecule Role

Protective antigen

Molecule Role Annotation

To test the potential of subunit vaccines against T. annulata infection, we immunized four groups of three calves with either recombinant (re-) (Tams1-1 and Tams1-2) proteins or naked DNA encoding these antigens. All calves vaccinated with ISCOMs proved to be protected from T. annulata infection and had generated antibodies against both re-(Tams1-1 and Tams1-2) at the time of challenge (d'Oliveira et al., 1997).

Related Vaccines(s)

T. annulata Tams1 Protein Vaccine

References

d'Oliveira et al., 1997: d'Oliveira C, Feenstra A, Vos H, Osterhaus AD, Shiels BR, Cornelissen AW, Jongejan F. Induction of protective immunity to Theileria annulata using two major merozoite surface antigens presented by different delivery systems. Vaccine. 1997; 15(16); 1796-1804. [PubMed: 9364686].

Gene Information

Gene Name

TA17050 merozoite-piroplasm surface antigen Tams1

NCBI Gene ID

3864438

Genbank Accession

AF214915

Chromosome No

Locus Tag

TA17050

Gene Starting Position

371414

Gene Ending Position

372259

DNA Sequence

>NW_001091929.1:371414-372259 Theileria annulata strain Ankara isolate clone C9 chromosome 1, *** SEQUENCING IN PROGRESS ***
TTTAAAGGAAGTAAAGGACTGATGAGAAGACGATGAGTACTGAGGCGAAGACTGCAAGGGGGGAGAACTT
GTCGACAACTGGTTTGTAATCGGTTGACCAGGATGAGTTCATGGCATTCAAGGCCTTGTTTGCATCTGCC
TGTGTCATTTGAACCCACTTATCGTCCTTAAGCTCGAAGTAGGTCTCCTTCAACCTTGAGTCACCGGTAT
AGAAGTAGTAGAGTTTGACGAACTTCTTGGAATCAGAACCAACAAAAACAACAACTTCAAGATACTTGGC
ATTGTTTGGTTTTCCGACTTCTTTCTTGTCGAAGGTGACTTTGGAAGGTTTAAATTCCTTTTTAAAGGTG
TACATCTTTCCAGTGCCGAAGGCGGAGGAGGTGAACAAAGATGTATCTTCGAACTTGGAAGCATCTAGTT
CCTTGGCGGATTTTCCCTTGAACAAGACATCATCGTAGTAGGTCTCGAATTTGACCTCAGAATATTCCTT
GTCTCCCTTCTTCTTGAACATCTTTGGCTGGGCAGGGTGAAGATTAAGTCTGAACCACTCATCGGATTCA
TGCTTAAGTTTGAATGCCTGTACTGGGGTATGTTTTGAGGTGTCAACATTGAACAAGGTCTTGTCTCCGA
CCTTAAGGGTCTTGAAACGGTAGCCATCCGCGACAGTTAACTCAGTGGTGTTAGAGTCGACGTTTTTAAA
GGTTACATTCTCACATGAAGTGAGAGTAACATCAAGAACAACATCTTTTTTTTCCTCCTTTTTCTTTTCA
TCCTCATTTGCAGCATTAACGGATGAGATAACGAAGAAGCTCAAATATAAGAACTTGAGGGTGGTCCTGG
ACAACA

Protein Information

NCBI Protein GI

84997996

Protein Accession

XP_953719

Protein pI

9.46

Protein Weight

29651.5

Protein Length

281

Protein Sequence

>XP_953719.1 merozoite-piroplasm surface antigen Tams1 [Theileria annulata]
MLSRTTLKFLYLSFFVISSVNAANEDEKKKEEKKDVVLDVTLTSCENVTFKNVDSNTTELTVADGYRFKT
LKVGDKTLFNVDTSKHTPVQAFKLKHESDEWFRLNLHPAQPKMFKKKGDKEYSEVKFETYYDDVLFKGKS
AKELDASKFEDTSLFTSSAFGTGKMYTFKKEFKPSKVTFDKKEVGKPNNAKYLEVVVFVGSDSKKFVKLY
YFYTGDSRLKETYFELKDDKWVQMTQADANKALNAMNSSWSTDYKPVVDKFSPLAVFASVLIVFSSVLYF
L

Epitope Information

IEDB Linear Epitope