VIOLIN: Vaccine Investigation and Online Information Network

BT1

General Information

Protegen ID

570

Sequence Strain (Species/Organism)

Leishmania donovani

VO ID

VO_0011160

Taxonomy ID

5661

Other Database IDs

CDD:273268
CDD:281135

Molecule Role

Protective antigen

Molecule Role Annotation

Immunization of mice with recombinant BT1 proteins (a biopterin transporter) from multigenic LD1 locus on chromosome 35 of L. donovani conferred partial protection against challenge with Leishmania donovani in a BALB/c mice (Sukumaran and Madhubala, 2004).

References

Sukumaran and Madhubala, 2004: Sukumaran B, Madhubala R. Leishmaniasis: current status of vaccine development. Current molecular medicine. 2004; 4(6); 667-679. [PubMed: 15357215].

Gene Information

Gene Name

BT1

NCBI Gene ID

13387967

Protein Information

Protein Name

unknown

NCBI Protein GI

703123

Protein pI

7.37

Protein Weight

64395.53

Protein Length

679

Protein Note

folate/biopterin transporter; TIGR00788

Protein Sequence

>AAA96729.1 unknown [Leishmania donovani]
MPPAPESPPPQVAKYVHPVSARVLRAAPFLGYIPVFSIAIRSFHPKVVVAICMQRLFEKGLANGLMRLSM
QPMLTGRYGLTGAMYQRLSTLYTLGWALNAFITVMADTFALFGYTKRWYCVVSAVGGGAFALLYGLLPAK
ESSAKPAAAFMFLAALFMSNIDVFAVALYSERIRQRPAAGPALVSWMWGTALIGIMISSVIQGPLSDNRL
THLGVYITAAILLLSGLLFVFNLFEERRNRAARLEDAMIEFLQNTKSASTDSTAGSLPSPHKPDGHLTID
SRVEEEGDDDDHDEQKAAAMDAQGFVRPRMDTYLCGAVEMNRDVLLRNWRMALFCLILTLGVIANALVNI
LGTRWDIMYVCIVVAVVVCVSSFFTLPLAIAKAVVFMYFNEILYLNLPGVLNTFYVAKPLCLPGGPHFSY
TFYNVMNGILGSIAGIGGTMVFTHLFPHHSYRFVMGLSAVLLPAASMFDLLILKRWNLVIGIPDHAMYIL
GDAIIYEVCDMLLNMPMMMLMCRIAPRGSESMVFALLASIYHLGTSTSSAIGYLLMETIWPVVTQGTCDY
SNAPWLVITGHIVAPVFILPLAYVLLPSARISDHIDHTGRKVMEAALPETRTEAAEEPIATTMKRDS

Epitope Information

IEDB Linear Epitope