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A2

General Information
Protegen ID 563
Sequence Strain (Species/Organism) Leishmania donovani
VO ID VO_0011153
Taxonomy ID 5671
Molecule Role Protective antigen
Molecule Role Annotation Study results show that a single intraperitoneal administration of the A2-recombinant L. tarentolae strain expressing the Leishmania donovani A2 antigen protects BALB/c mice against L. infantum challenge and that protective immunity is associated with high levels of IFN-gamma production prior and after challenge (Mizbani et al., 2009).
Related Vaccines(s) Leishmania vaccine using recombinant L. tarentolae strain expressing A2 antigen
References
Mizbani et al., 2009: Mizbani A, Taheri T, Zahedifard F, Taslimi Y, Azizi H, Azadmanesh K, Papadopoulou B, Rafati S. Recombinant Leishmania tarentolae expressing the A2 virulence gene as a novel candidate vaccine against visceral leishmaniasis. Vaccine. 2009; 28(1); 53-62. [PubMed: 19818721].
Gene Information
Gene Name A2
Protein Information
Protein Name stage-specific S antigen-like protein
NCBI Protein GI 30385439
Protein pI 4.19
Protein Weight 9285.64
Protein Length 194
Protein Note zymodeme MON-29
Protein Sequence
>AAP21105.1 stage-specific S antigen-like protein [Leishmania infantum]
MKIRSVRPLVVLLVCVAAVLALSASAEPHKAAVDAGPLSVDVGPLSVDVGPLSVGPQSVGPLSVGPQSVD
PLSVDVGPLSVGPQSVGPLSVDVGPLSVGPQSVGPLSVGLQAVDVSPVS

Epitope Information
IEDB Linear Epitope