VIOLIN: Vaccine Investigation and Online Information Network

NS3

General Information

Protegen ID

557

Sequence Strain (Species/Organism)

Japanese encephalitis virus

VO ID

VO_0011148

Taxonomy ID

11072

Other Database IDs

CDD:279317
CDD:214692
CDD:284962
CDD:238005
CDD:304359
CDD:238034

Molecule Role

Protective antigen

Molecule Role Annotation

Researchers constructed plasmid DNAs encoding JE virus proteins. Cytotoxic T lymphocytes (CTLs) were induced by NS3 in a mouse model. Three immunizations with pUJENS3 provided a 50% partial protection from a lethal dose of JE virus (Konishi et al., 2003).

Related Vaccines(s)

Japanese encephalitis virus DNA vaccine pUJENS3

References

Konishi et al., 2003: Konishi E, Ajiro N, Nukuzuma C, Mason PW, Kurane I. Comparison of protective efficacies of plasmid DNAs encoding Japanese encephalitis virus proteins that induce neutralizing antibody or cytotoxic T lymphocytes in mice. Vaccine. 2003; 21(25-26); 3675-3683. [PubMed: 12922097].

Gene Information

Gene Name

NS3

Protein Information

Protein Name

non-structural protein NS3

NCBI Protein GI

27696332

Protein pI

7.14

Protein Weight

64684.98

Protein Length

699

Protein Note

proteinase and putative helicase

Protein Sequence

>NP_775670.1 non-structural protein NS3 [Japanese encephalitis virus]
GGVFWDTPSPKPCSKGDTTTGVYRIMARGILGTYQAGVGVMYENVFHTLWHTTRGAAIMSGEGKLTPYWG
SVKEDRIAYGGPWRFDRKWNGTDDVQVIVVEPGKAAVNIQTKPGVFRTPFGEVGAVSLDYPRGTSGSPIL
DSNGDIIGLYGNGVELGDGSYVSAIVQGDRQEEPVPEAYTPNMLRKRQMTVLDLHPGSGKTRKILPQIIK
DAIQQRLRTAVLAPTRVVAAEMAEALRGLPVRYQTSAVQREHQGNEIVDVMCHATLTHRLMSPNRVPNYN
LFVMDEAHFTDPASIAARGYIATKVELGEAAAIFMTATPPGTTDPFPDSNAPIHDLQDEIPDRAWSSGYE
WITEYAGKTVWFVASVKMGNEIAMCLQRAGKKVIQLNRKSYDTEYPKCKNGDWDFVITTDISEMGANFGA
SRVIDCRKSVKPTILEEGEGRVILGNPSPITSASAAQRRGRVGRNPNQVGDEYHYGGATSEDDSNLAHWT
EAKIMLDNIHMPNGLVAQLYGPEREKAFTMDGEYRLRGEEKKNFLELLRTADLPVWLAYKVASNGIQYTD
RRWCFDGPRTNAILEDNTEVEIVTRMGERKILKPRWLDARVYADHQALKWFKDFAAGKR

Epitope Information

IEDB Linear Epitope