VIOLIN: Vaccine Investigation and Online Information Network

NA

General Information

Protegen ID

530

Sequence Strain (Species/Organism)

Influenza A virus (A/Aichi/2/1968(H3N2))

VO ID

VO_0011123

Taxonomy ID

387139

Other Database IDs

CDD:271235

Molecule Role

Protective antigen

Molecule Role Annotation

The protective effect of neuraminidase (NA) was studied in a mouse protection test using isolated neuraminidase of A2/Aichi/68(H3N2) virus and the complete recombinant virus A/eq(Heq-1)-HK(N2) as antigens. Immunized mice were protected against A2/Aichi(H3N2) challenge virus; however, the protection rate was low in comparison to animals immunized with comparable amounts of the complete A2/68(H3N2) virus9 (Reichert and Mauler, 1975).

References

Reichert and Mauler, 1975: Reichert E, Mauler R. Effect of neuraminidase on potency of inactivated influenza virus vaccines in mice. Developments in biological standardization. 1975; 28; 319-323. [PubMed: 1126575].

Gene Information

Gene Name

Protein Information

Protein Name

neuraminidase

NCBI Protein GI

46401580

Protein pI

6.7

Protein Weight

49574.86

Protein Length

546

Protein Note

synonym: Influenza A virus (A/Aichi/2/68(H3N2))

Protein Sequence

>BAD16642.1 neuraminidase [Influenza A virus (A/Aichi/2/1968(H3N2))]
MNPNQKIITIGSVSLTIATVCFLMQIAILVTTVTLHFKQYECDSPASNQVMPCEPIIIERNITEIVYLNN
TTIDKEKCPKVVEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDHGKCYQFALGQGTTL
DNKHSNDTIHDRIPHRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYDGR
LVDSIGSWSQNILRTQESECVCINGTCTVVMTDGSASGRADTRILFIEEGKIVHISPLSGSAQHVEECSC
YPRYPGVRCICRDNWKGSNRPVVDINMEDYSIDSSYVCSGLVGDTPRNDDRSSNSNCRNPNNERGNQGVK
GWAFDNGDDVWMGRTISKDLRSGYETFKVIGGWSTPNSKSQINRQVIVDSDNRSGYSGIFSVEGKSCINR
CFYVELIRGRKQETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

Epitope Information

IEDB Linear Epitope