VIOLIN: Vaccine Investigation and Online Information Network

ICP27

General Information

Protegen ID

504

Sequence Strain (Species/Organism)

Herpes simplex virus type 1

VO ID

VO_0011101

Taxonomy ID

10298

Other Database IDs

CDD:293457
CDD:283185

Molecule Role

Protective antigen

Molecule Role Annotation

Epitopes from the ICP27 (H1, H2), glycoprotein B (gB) and glycoprotein D (gD) proteins of HSV-1 were attached to either the J TCBL/ICBL or the G TCBL/ICBL. The JH1, JH2, JgB and JgD vaccines elicited DTH responses without antibody but conferred protection upon lethal challenge with HSV (Goel et al., 2005).

Related Vaccines(s)

Herpes simplex virus DNA vaccine ICP-27 DNA encoding ICP-27

References

Goel et al., 2005: Goel N, Zimmerman DH, Rosenthal KS. Ligand epitope antigen presentation system vaccines against herpes simplex virus. Frontiers in bioscience : a journal and virtual library. 2005; 10; 966-974. [PubMed: 15569635].

Gene Information

Gene Name

ICP27

Protein Information

Protein Name

ICP27

NCBI Protein GI

75812153

Protein pI

6.82

Protein Weight

53658

Protein Length

566

Protein Note

Identical sequence is also seen in starin: BBY-C-1802;
laboratory host: Vero cell, human embryonic lung cell

Protein Sequence

>BAE44982.1 ICP27 [Human alphaherpesvirus 1]
MATDIDMLIDLGLDLSDSDLDEDPPEPAESRRDDLASDSSGECSSSDEDMEDPHGEDGPEPILDAARPAV
RPSRPEDPGVPSTQTPRPTERQGPNDPQPAPHSVWSRLGARRPSCSPEQHGGKVARLQPPPTKAQPARGG
RRGRRRGRGRGGPGAADGLSDPRRRAPRTNRNPGGPRPGAGWTDGPGAPHGEAWRGSEQPDPPGGPRTRG
VRQAPPPLMTLAIAPPPADPRAPAPERKAPAADTIDATTRLVLRSISERAAVDRISESFGRSAQVMHDPF
GGQPFPAANSPWAPVLADQGGPFDAETRRVSWETLVAHGPSLYRTFAGNPRAASTAKAMRDCVLRQENFI
EALASADETLAWCKMCIHHNLPLRPQDPIIGTAAAVLDNLATRLRPFLQCYLKARGLCGLDELCSRRRLA
DIKDIASFVFVILARLANRVERGVAEIDYATLGVGVGEKMHFYLPGACMAGLIEILDTHRQECSSRVCEL
TASHIVAPPYVHGKYFYCNSLF

Epitope Information

IEDB Linear Epitope