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SodB from F. tularensis SCHU S4

General Information

Protegen ID

475

Sequence Strain (Species/Organism)

Francisella tularensis subsp. tularensis SCHU S4

VO ID

VO_0011077

Taxonomy ID

177416

Molecule Role

Virmugen

Molecule Role Annotation

C57BL/6 mice were vaccinated intranasally (i.n.) with the sodB(Ft) mutant and challenged i.n. with lethal doses of F. tularensis SchuS4. SodB(Ft) vaccinated mice following SchuS4 challenge exhibited significantly reduced bacterial burden in lungs, liver, and spleen, regulated production of pro-inflammatory cytokines, and less severe histopathological lesions compared to the LVS vaccinated mice. The sodB(Ft) vaccination induced a potent humoral immune response and protection against SchuS4 required both CD4 and CD8 T cells in the vaccinated mice (Bakshi et al., 2008).

COG

COG0605P, under P: Inorganic ion transport and metabolism

Related Vaccines(s)

sodB(Ft)

References

Bakshi et al., 2008: Bakshi CS, Malik M, Mahawar M, Kirimanjeswara GS, Hazlett KR, Palmer LE, Furie MB, Singh R, Melendez JA, Sellati TJ, Metzger DW. An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain. Vaccine. 2008; 26(41); 5276-5288. [PubMed: 18692537].

Gene Information

Gene Name

SodB from F. tularensis SCHU S4

NCBI Gene ID

3190713

Genbank Accession

AJ749949

Locus Tag

FTT_0068

Gene Starting Position

70160

Gene Ending Position

70738

DNA Sequence

>gi|255961454:70160-70738 Francisella tularensis subsp. tularensis SCHU S4, complete genome
AATGAAATTTGAATTACCAAAACTACCTTACGCTGTTGATGCATTAGAGTCAACAATATCAAAAGAAACA
ATAGAGTATCACTATGGTAAACATCATCAAACATATGTAACTAATCTAAATAATTTAGTTGAGGGTACAG
AGCACGATGGCAGAAACCTAGAAGAAATCGTAAAAACTTCTAATGGCGGAATATTTAATAACGCTGCTCA
AGTTTTTAATCATACTTTTTACTGGAATTGTTTAACTCCAAACAAAACAGAAGCTTCAAGTCAGTTAAAA
GCAGCATTGATCGAGACATTTGGTTCTGTAGAAAATTTTAAAGAACAATTCTCTAAGGCAGCTATTGCAA
CATTTGGTTCTGGTTGGGCTTGGTTAGTAAAAAATACTGAAGGTAAACTTGAAATAGTAACTACAAGTAA
CGCTGGTTGCCCATTAACAGAGAACAAAAAGCCATTGCTAACTTTTGATGTTTGGGAGCACGCATACTAT
ATTGATTATCGTAATGCTAGACCTAAATATGTTGAAGCATTATGGGATATCGTAAACTGGCAATTTGTTT
CTGAGCAATTCGCTGATTA

Protein Information

Protein Name

superoxide dismutase (Fe)

NCBI Protein GI

56707247

Protein Accession

YP_169143

3D structure: PDB ID

3H1S

Protein pI

5.29

Protein Weight

20748.47

Protein Length

192

Protein Note

Similar to SODF_ECOLI (P09157) Superoxide dismutase [Fe] from E. coli (192 aa). FASTA: opt: 896 Z-score: 1143.2 E(): 8.8e-56 Smith-Waterman score: 896; 66.316 identity in 190 aa overlap

Protein Sequence

>gi|56707247|ref|YP_169143.1| superoxide dismutase (Fe) [Francisella tularensis subsp. tularensis SCHU S4]
MKFELPKLPYAVDALESTISKETIEYHYGKHHQTYVTNLNNLVEGTEHDGRNLEEIVKTSNGGIFNNAAQ
VFNHTFYWNCLTPNKTEASSQLKAALIETFGSVENFKEQFSKAAIATFGSGWAWLVKNTEGKLEIVTTSN
AGCPLTENKKPLLTFDVWEHAYYIDYRNARPKYVEALWDIVNWQFVSEQFAD

Epitope Information

IEDB Linear Epitope