VIOLIN: Vaccine Investigation and Online Information Network

cathepsin B1 (SmCB1)

General Information

Protegen ID

4382

Sequence Strain (Species/Organism)

Schistosoma mansoni

Taxonomy ID

6183

Other Database IDs

CDD:239111

Molecule Role

Protective antigen

Molecule Role Annotation

(Tallima et al., 2017)

References

Tallima et al., 2017: Tallima H, Dvořák J, Kareem S, Abou El Dahab M, Abdel Aziz N, Dalton JP, El Ridi R. Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase. PLoS neglected tropical diseases. 2017; 11(3); e0005443. [PubMed: 28346516].

Gene Information

Gene Name

cathepsin B1 (SmCB1)

Protein Information

Protein Name

cathepsin B1 (SmCB1)

NCBI Protein GI

4I07_A

Protein pI

8.27

Protein Weight

27990.962

Protein Length

320

Protein Note

Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an...; cd02620

Protein Sequence

>pdb|4I07|A Chain A, Cathepsin B-like Peptidase (c01 Family)
VEIPSSFDSRKKWPRCKSIATIRDQSRCGSXWAFGAVEAMSDRSCIQSGGKQNVELSAVDLLSCCESCGL
GCEGGILGPAWDYWVKEGIVTGSSKENHAGCEPYPFPKCEHHTKGKYPPCGSKIYKTPRCKQTCQKKYKT
PYTQDKHRGKSSYNVKNDEKAIQKEIMKYGPVEAGFTVYEDFLNYKSGIYKHITGETLGGHAIRIIGWGV
ENKAPYWLIANSWNEDWGENGYFRIVRGRDECSIESEVTAGRIN

Epitope Information

IEDB Linear Epitope