VIOLIN: Vaccine Investigation and Online Information Network

gatB

General Information

Protegen ID

424

Sequence Strain (Species/Organism)

Chlamydophila abortus

VO ID

VO_0010880

Taxonomy ID

218497

Other Database IDs

CDD:235489
EnsemblGenomes-Gn:CAB287
EnsemblGenomes-Tr:CAH63737
GOA:Q5L6I8
InterPro: IPR003789
InterPro: IPR004413
InterPro: IPR006075
InterPro: IPR017958
InterPro: IPR017959
InterPro: IPR018027

Molecule Role

Protective antigen

Molecule Role Annotation

Genetic immunization was used to functionally test the genes of C. abortus as vaccines in a mouse challenge system. Glu-tRNA Gln Amidotransferase (CP #3, gatB) was found to be protective. Three of the clones (CP #1–3) elicited protection that was statistically higher than the unvaccinated control, which has high variance (Stemke-Hale et al., 2005).

Note: Part of CP #3 also belongs to gatA

Related Vaccines(s)

C. abortus DNA vaccine encoding GatA/GatB

References

Stemke-Hale et al., 2005: Stemke-Hale K, Kaltenboeck B, DeGraves FJ, Sykes KF, Huang J, Bu CH, Johnston SA. Screening the whole genome of a pathogen in vivo for individual protective antigens. Vaccine. 2005; 23(23); 3016-3025. [PubMed: 15811648].

Gene Information

Gene Name

gatB

Protein Information

Protein Name

aspartyl/glutamyl-tRNA amidotransferase subunit B

NCBI Protein GI

62147986

Protein pI

5.67

Protein Weight

51934.12

Protein Length

583

Protein Note

aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; PRK05477

Protein Sequence

>CAH63737.1 aspartyl/glutamyl-tRNA amidotransferase subunit B [Chlamydia abortus S26/3]
MSDVYADWESVIGLEVHVELNTKSKLFSCARNRFGDEPNTNISPVCTGMPGSLPVLNKEAVRKAVLFGCA
VEGEVALLSRFDRKSYFYPDSPRNFQITQFEHPIVRGGHIKAIVHGEERHFELAQAHIEDDAGMLKHFGE
FAGVDYNRAGVPLIEIVSKPCMFCADDAVAYATALVSLLDYIGISDCNMEEGSVRFDVNISVRPKGSEEL
RNKVEIKNMNSFAFMAQALEAERCRQIDAYLDNPNADPKTVIPGATYRWDPEKKKTVLMRLKERAEDYKY
FIEPDLPVLQLTEAYIDEIRHTLPELPFNKYQRYLHEYALAEDIAAILISDKHSAHFFELAAQECKNYRA
LSNWLTVEFAGRCKLKGKNLAFSGILPSSVAQLVNFIDQGVITGKIAKDIADMMMESPEKSPETILKENP
EMLPMTDESALVAIISEVITANPQSVVDYKSGKTKALGFLVGQIMKRTQGKAPPNRVNELLLVELSK

Epitope Information

IEDB Linear Epitope