VIOLIN: Vaccine Investigation and Online Information Network

phtE

General Information

Protegen ID

4160

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

Taxonomy ID

1313

Other Database IDs

CDD:331999
CDD:309414

Molecule Role

Protective antigen

Molecule Role Annotation

Seven proteins induced protective responses, in terms of reduced lung burdens of the serotype 3 pneumococci. Three of the protective proteins were histidine triad protein family members (PhtB, PhtD and PhtE). Four other proteins, all bearing LPXTG linkage domains, also had activity in this model (PrtA, NanA, PavB and Eng).(Anderson et al., 2016)

References

Anderson et al., 2016: Anderson RJ, Guru S, Weeratna R, Makinen S, Falconer DJ, Sheppard NC, Lang S, Chang B, Goenaga AL, Green BA, Merson JR, Gracheck SJ, Eyles JE. In vivo screen of genetically conserved Streptococcus pneumoniae proteins for protective immunogenicity. Vaccine. 2016; 34(50); 6292-6300. [PubMed: 27816374].

Gene Information

Gene Name

phtE

Protein Information

Protein Name

pneumococcal histidine triad protein E

NCBI Protein GI

CKA60496

Protein pI

5.25

Protein Weight

125033.92

Protein Length

1276

Protein Note

Streptococcal histidine triad protein; cl27178

Protein Sequence

>CKA60496.1 pneumococcal histidine triad protein E [Streptococcus pneumoniae]
MKFSKKYIAAGSAVIVSLSLCAYALNQHRSQENKDNNRVSYVDGSQSSQKSENLTPDQVSQKEGIQAEQI
VIKITDQGYVTSHGDHYHYYNGKVPYDALFSEELLMKDPNYQLKDGDIVNEVKGGYIIKVDGKYYVYLKD
AAHADNVRTKDEINRQKQEHVKDNEKVSSDVAVARSQGRYTTDDGYVFNPADIIEDTGDAYIVPHGGHYH
YIPKSDLSASELAAAKAHLAGKNTQPSQLSYSSAASDNNTQSVAQGSTSKPESKVENLQSLLKELYDLPS
DQRYSESDGLVFDPAKIISRTPNGVAIPHGDHYHFIPYSKLSALEEKIARMVPIGGTGSTVSTNAKPNAV
ASSLGSLSNNPSSLTTSRELSSTSDGYIFNPKDIVEETATAYIVRHGDHFHYIPKSNQIGQPTLPNNGLT
TPSPSLPINPGTSHEEHEEDGHGFDANRIIAEDAAGFIMTHGNHNHYFFKKDLTADQIKAAQDHLKGANT
ATPNPAHDDDHDEDHHGHHHGHHHDEDHDHGFDADRVISEDDQGFVMTHGNHNHYFFKKDLTAEQIKAAQ
DHLKAHHGAEPVKPLAKTVESFSRDASDEEKIAYISKTYGVPLEAIRISNGFFVFGNPDQAYDPTHIHPY
AVRKEHVRLPLQTGNPELDFLNELYTTALRDGVSPYSLQVENGSFVIPHGDHNHYIKVQTKGYEVALKNK
IPALQSNYQPGAFDEKGVLAKVDQLLAESRNVYKDDPIKQRQIELALGQFTENMKKLATNSTAGYLKTLD
LFDKQYIHIDESVKPVETSALDKKYQALIDKINTLDTDSYGLPKKDLLVRLQEAKLAKDEAALAAVESQL
QALQDFNDRTGDTSVEYIKYFYEHVNDSRLSDELRNKVANLTFTLYQSQSFRKAVDLNKLFPSIYQTKQE
VEEALKNQPATAKVNETVLDKEKVDNQSAKQAIYEFLKDLYPDLKKEEHVNHVSKEEVESLLSKASQLLE
QIHEEGIRQSLAEEVENLKAATNKADADLDEVNSQVKDVLTRIASALQQEKENAEQDPQTLVLYQKLYDI
LISLHSYLENNKGSDEDFDKVDALLDQLSAKSKDKAALLELTKAILVLNHQIQSKASASEETSPARNAEA
NGDNSSAENQPNATAESNSETASDENKPSNTRDSKPTEPALENETTESSTTTGNQAKPAE

Epitope Information

IEDB Linear Epitope