VIOLIN: Vaccine Investigation and Online Information Network

pspA

General Information

Protegen ID

4154

Sequence Strain (Species/Organism)

Streptococcus pneumoniae

Taxonomy ID

1313

Other Database IDs

CDD:299863

Molecule Role

Protective antigen

Molecule Role Annotation

(Tostes et al., 2017)

References

Tostes et al., 2017: Tostes RO, Rodrigues TC, da Silva JB, Schanoski AS, Oliveira ML, Miyaji EN. Protection Elicited by Nasal Immunization with Recombinant Pneumococcal Surface Protein A (rPspA) Adjuvanted with Whole-Cell Pertussis Vaccine (wP) against Co-Colonization of Mice with Streptococcus pneumoniae. PloS one. 2017; 12(1); e0170157. [PubMed: 28103277].

Gene Information

Gene Name

pspA

Protein Information

Protein Name

PspA

NCBI Protein GI

AAF27715

Protein pI

4.59

Protein Weight

49428.4

Protein Length

522

Protein Note

The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013

Protein Sequence

>AAF27715.1 PspA, partial [Streptococcus pneumoniae]
MNKKKMILTSLASVAILGTGFVASSPTFVRAEESPQVVEKSSLEKKYEEAKAKADTAKKDYETAKKKAED
AQKKYDEDQKKTEDKAKAVKKVDEERQKANLAVQKAYVEYREAKDKASAEKKIEEAKRKQKEANKKFNEE
QAKVVPEAKELAATKQKAEKAKKDAEVAKEKYDKAVQEVEVEKNKILEQDAENEKKIDVLQNKVADLEKG
IAPYQNKVAELNKEIARLQSDLKDAEENNVEDYIKEGLEQAIADKKAELATTQQNIDKTQKDLEDAELEL
EKVLATLDPEGKTQDELDKEAAEDANIEALQNKVADLENKVAELDKEVTRLQSDLKDAEENNVEDYVKEG
LEKALTDKKVELNNTQKALDTAPKALDTALNELGPDGDEEETPAPAPKPEQPAEQPKPAPAPKPEKTDDQ
QAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAP

Epitope Information

IEDB Linear Epitope