VIOLIN: Vaccine Investigation and Online Information Network

inlA

General Information

Protegen ID

4135

Sequence Strain (Species/Organism)

Streptococcus pyogenes M1 GAS

Taxonomy ID

160490

Other Database IDs

CDD:331999
CDD:275380
CDD:227223

Molecule Role

Protective antigen

Molecule Role Annotation

(Bensi et al., 2012)

References

Bensi et al., 2012: Bensi G, Mora M, Tuscano G, Biagini M, Chiarot E, Bombaci M, Capo S, Falugi F, Manetti AG, Donato P, Swennen E, Gallotta M, Garibaldi M, Pinto V, Chiappini N, Musser JM, Janulczyk R, Mariani M, Scarselli M, Telford JL, Grifantini R, Norais N, Margarit I, Grandi G. Multi high-throughput approach for highly selective identification of vaccine candidates: the Group A Streptococcus case. Molecular & cellular proteomics : MCP. 2012; 11(6); M111.015693. [PubMed: 22286755].

Gene Information

Gene Name

inlA

Protein Information

Protein Name

putative internalin A precursor

NCBI Protein GI

NP_269467

Protein pI

6.3

Protein Weight

83906.01

Protein Length

882

Protein Note

Streptococcal histidine triad protein; cl27178

Protein Sequence

>NP_269467.1 putative internalin A precursor [Streptococcus pyogenes M1 GAS]
MKTKKVIILVGLLLSSQLTLIACQSRGNGTYPIKTKQSRKGMTSNKIKPIKKSKKTNKTHKGVAGVDFPT
DDGFILTKDSKILSKTDQGIVVDHDGHSHFIFYADLKGSPFEYLIPKGASLAKPAVAQRAASQGTSKVAD
PHHHYEFNPADIVAEDALGYTVRHDDHFHYILKSSLSGQTQAQAKQVATRLPQTSSLVSTATANGIPGLH
FPTSDGFQFNGQGIVGVTKDSILVDHDGHLHPISFADLRQGGWAHVADQYDPAKKAEKPAETHQTPELSE
REKEYQEKLAYLAEKLGIDPSTIKRVETQDGKLGLEYPHHDHAHVLMLSDIEIGKDIPDPHAIEHARELE
KHKVGMDTLRALGFDEEVILDIVRTHDAPTPFPSNEKDPNMMKEWLATVIKLDLGSRKDPLQRKGLSLLP
NLETLGIGFTPIKDISPVLQFKKLKQLLMTKTGVTDYRFLDNMPQLEGIDISQNNLKDISFLSKYKNLTL
VAAADNGIEDIRPLGQLPNLKFLVLSNNKISDLSPLASLHQLQELHIDNNQITDLSPVSHKESLTVVDLS
RNADVDLATLQAPKLETLMVNDTKVSHLDFLKNNPNLSSLSINRAQLQSLEGIEASSVIVRVEAEGNQIK
SLVLKDKQGSLTFLDVTGNQLTSLEGVNNFTALDILSVSKNQLTNVNLSKPNKTVTNIDISHNNISLADL
KLNEQHIPEAIAKNFPAVYEGSMVGNGTAEEKAAMATKAKESAQEASESHDYNHNHTYEDEEGHAHEHRD
KDDHDHEHEDENEAKDEQNHAD

Epitope Information

IEDB Linear Epitope