VIOLIN: Vaccine Investigation and Online Information Network

lip40

General Information

Protegen ID

4087

Sequence Strain (Species/Organism)

Actinobacillus pleuropneumoniae

Taxonomy ID

715

Other Database IDs

CDD:295696

Molecule Role

Protective antigen

Molecule Role Annotation

Recombinant Lip40 (rLip40) produced in Escherichia coli BL21(DE3) was specifically recognized by porcine convalescent serum directed against A. pleuropneumoniae. Lip40 also protected 75% of mice from fatal virulent A. pleuropneumoniae infection.(Hu et al., 2015)

References

Hu et al., 2015: Hu X, Yan H, Liu K, Hu J, Qi C, Yang J, Liu Y, Zhao J, Liu J. Identification and characterization of a novel stress-responsive outer membrane protein Lip40 from Actinobacillus pleuropneumoniae. BMC biotechnology. 2015; 15; 106. [PubMed: 26608465].

Gene Information

Gene Name

lip40

Protein Information

Protein Name

lipoprotein Lip40

NCBI Protein GI

AKJ32477

Protein pI

9.77

Protein Weight

31139.75

Protein Length

368

Protein Note

Transferrin binding protein-like solute binding protein; cl03152

Protein Sequence

>AKJ32477.1 lipoprotein Lip40 [Actinobacillus pleuropneumoniae]
MKNITKFAVTLLAGLVITACGSKNHSIDIKPKSDKPKQEQPKQPQPKQDQPKQEQPKQEQPKKDQPKQDQ
PKQEQPKQDQPKDKTSGGVFIVEGVSKNLPQLTKEKLTDANLNSIKVDGIEIKFADATKAEGNWKVSPDN
SLVVCCDKYSSVRFGVYESKGKSYSFYNGNATAEMPTSGKFTYTGDAYLLASVVGNGAESIGTSKFEADF
GTKKLTGTLTFDKLKDSKNVDIDSKISGNSFTGKATFDSFKGTDAIVEGKFYGENAKELAGAFDSAKEKG
AKLGDKSWGGVFGAKQQK

Epitope Information

IEDB Linear Epitope