VIOLIN: Vaccine Investigation and Online Information Network

flu

General Information

Protegen ID

3993

Sequence Strain (Species/Organism)

Escherichia coli

Taxonomy ID

511145

Other Database IDs

CDD:315649
CDD:225999
CDD:328937
UniProtKB/UniProt: P39180
ASAP:ABE-0006642
ECOCYC:G7080
EcoGene:EG12686

Molecule Role

Protective antigen

Molecule Role Annotation

Vaccination of mice with recombinant passenger domains from either pAT or Ag43 afforded protection against intestinal colonization with ETEC (Harris et al., 2011).

References

Harris et al., 2011: Harris JA, Roy K, Woo-Rasberry V, Hamilton DJ, Kansal R, Qadri F, Fleckenstein JM. Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates. PLoS neglected tropical diseases. 2011; 5(12); e1428. [PubMed: 22163060].

Gene Information

Gene Name

flu

Protein Information

Protein Name

CP4-44 prophage; self recognizing antigen 43 (Ag43) autotransporter

NCBI Protein GI

49176177

Protein pI

6.13

Protein Weight

98576.16

Protein Length

1180

Protein Note

Extended Signal Peptide of Type V secretion system; pfam13018

Protein Sequence

>YP_026164.1 CP4-44 prophage; self recognizing antigen 43 (Ag43) autotransporter [Escherichia coli str. K-12 substr. MG1655]
MKRHLNTCYRLVWNHMTGAFVVASELARARGKRGGVAVALSLAAVTSLPVLAADIVVHPGETVNGGTLAN
HDNQIVFGTTNGMTISTGLEYGPDNEANTGGQWVQDGGTANKTTVTSGGLQRVNPGGSVSDTVISAGGGQ
SLQGRAVNTTLNGGEQWMHEGAIATGTVINDKGWQVVKPGTVATDTVVNTGAEGGPDAENGDTGQFVRGD
AVRTTINKNGRQIVRAEGTANTTVVYAGGDQTVHGHALDTTLNGGYQYVHNGGTASDTVVNSDGWQIVKN
GGVAGNTTVNQKGRLQVDAGGTATNVTLKQGGALVTSTAATVTGINRLGAFSVVEGKADNVVLENGGRLD
VLTGHTATNTRVDDGGTLDVRNGGTATTVSMGNGGVLLADSGAAVSGTRSDGKAFSIGGGQADALMLEKG
SSFTLNAGDTATDTTVNGGLFTARGGTLAGTTTLNNGAILTLSGKTVNNDTLTIREGDALLQGGSLTGNG
SVEKSGSGTLTVSNTTLTQKAVNLNEGTLTLNDSTVTTDVIAQRGTALKLTGSTVLNGAIDPTNVTLASG
ATWNIPDNATVQSVVDDLSHAGQIHFTSTRTGKFVPATLKVKNLNGQNGTISLRVRPDMAQNNADRLVID
GGRATGKTILNLVNAGNSASGLATSGKGIQVVEAINGATTEEGAFVQGNRLQAGAFNYSLNRDSDESWYL
RSENAYRAEVPLYASMLTQAMDYDRIVAGSRSHQTGVNGENNSVRLSIQGGHLGHDNNGGIARGATPESS
GSYGFVRLEGDLMRTEVAGMSVTAGVYGAAGHSSVDVKDDDGSRAGTVRDDAGSLGGYLNLVHTSSGLWA
DIVAQGTRHSMKASSDNNDFRARGWGWLGSLETGLPFSITDNLMLEPQLQYTWQGLSLDDGKDNAGYVKF
GHGSAQHVRAGFRLGSHNDMTFGEGTSSRAPLRDSAKHSVSELPVNWWVQPSVIRTFSSRGDMRVGTSTA
GSGMTFSPSQNGTSLDLQAGLEARVRENITLGVQAGYAHSVSGSSAEGYNGQATLNVTF

Epitope Information

IEDB Linear Epitope