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espB

General Information
Protegen ID 3987
Sequence Strain (Species/Organism) Escherichia coli O157:H7
Taxonomy ID 1286877
Molecule Role Protective antigen
Molecule Role Annotation Immunized mice exhibited significant protection against E. coli O157:H7 colonization, as indicated by the reduced amount and/or duration of the bacterial fecal shedding, which demonstrate the protective potential of EspB as an oral vaccine against EHEC infection (Ahmed et al., 2014)
References
Ahmed et al., 2014: Ahmed B, Loos M, Vanrompay D, Cox E. Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization. Vaccine. 2014; 32(31); 3909-3916. [PubMed: 24877767].
Gene Information
Gene Name espB
Protein Information
Protein Name espB
NCBI Protein GI EIP05354
Protein pI 5.48
Protein Weight 27035.18
Protein Length 326
Protein Sequence
>EIP05354.1 espB [Escherichia coli O157:H7 str. TW14313]
MLEIQKLLGKMVTLLQDYQQKQLAQSYQIQQAVFESQNKAIEEKKAAATAALVGGIISSALGILGSFAAM
NNAAKGAGEIAEKASSASSKAAGAASEVANKALVKATESVADVAEEASSAMQKAMATTTKAASRASGVAD
DVAKASDFAEDLADAAEKTSRINKLLNSVDKLTNTTAFVAVTSLAEGTKTLPTTISESVKSTHEVNEQRA
KSLENFQQGNLELYKQDVRRTQDDITTRLRDITSAVRDLLEVQNRMGQSGRLAG
Epitope Information
IEDB Linear Epitope