VIOLIN: Vaccine Investigation and Online Information Network

fimH

General Information

Protegen ID

3978

Sequence Strain (Species/Organism)

Escherichia coli

Taxonomy ID

562

Other Database IDs

CDD:198456
CDD:312615
CDD:321493

Molecule Role

Protective antigen

Molecule Role Annotation

Of the vaccine preparations, Fusion, Fusion + CT, and FimH admixed with FliC and CT showed the best protection against UPEC (Asadi et al., 2016).

References

Asadi et al., 2016: Asadi Karam MR, Habibi M, Bouzari S. Use of flagellin and cholera toxin as adjuvants in intranasal vaccination of mice to enhance protective immune responses against uropathogenic Escherichia coli antigens. Biologicals : journal of the International Association of Biological Standardization. 2016; 44(5); 378-386. [PubMed: 27461240].

Gene Information

Gene Name

fimH

Protein Information

Protein Name

FimH

NCBI Protein GI

AGA03820

Protein pI

7.9

Protein Weight

28487.08

Protein Length

342

Protein Note

uropathogenic strain

Protein Sequence

>AGA03820.1 FimH [Escherichia coli]
MKRVITLFAVLLMGWSVNAWSFACKTANGTAIPIGGGSANVYVNLAPAVNVGQNLVVDLSTQIFCHNDYP
ETITDYVTLQRGSAYGGVLSNFSGTVKYSGSSYPFPTTSETPRVVYNSRTDKPWPVALYLTPVSSAGGVA
IKAGSLIAVLILRQTNNYNSDDFQFVWNIYANNDVVVPTGGCDVSARDVTVTLPDYPGSVPIPLTVYCAK
SQNLGYYLSGTTADAGNSIFTNTASFSPAQGVGVQLTRNGTIIPANNTVSLGAVGTSAVSLGLTANYART
GGQVTAGNVKSIIGVTFVYQ

Epitope Information

IEDB Linear Epitope