Compared to non-immunized mice, immunization with Epivac alone or with a Th1 adjuvant significantly reduced H. pylori colonization, and better protection was observed when an adjuvant was used (Li et al., 2012).
Li et al., 2012: Li HB, Zhang JY, He YF, Chen L, Li B, Liu KY, Yang WC, Zhao Z, Zou QM, Wu C. Systemic immunization with an epitope-based vaccine elicits a Th1-biased response and provides protection against Helicobacter pylori in mice. Vaccine. 2012; 31(1); 120-126. [PubMed: 23137845].
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173
Protein Sequence
>WP_130778457.1 type IV secretion system oncogenic effector CagA [Helicobacter pylori]
MVNETIDQTTTPDQTDFVPQRFINNLQVAFIKVDNAVASFDPDQKPIVDKNDRDNRQAFEKISQLREEYA
NKAIKNPTKKNQYFSDFINKSNDLINKDNLIAVDSSVESFRKFGDQRYQIFTSWVSLQKDPSKINTQQIR
NFMENIIQPPISDDKEKAEFLRSAKQSFAGIIIGNQIRSDEKFMGVFDESLKVRQEAEKNEEPAGGDWLD
IFLSFVFNKKQSSDLKETLNQEPRPDVEQNLATTTTDIQGLPPEARDLLDERGNFFKFTLGDVEMLDVEG
VADKDPNYKFNQLLIHNNALSSVLMGSHSSIEPEKVSLLYGDNGGPEARHDWNATVGYKNQQGSNVATLI
NAHLNNGSGLVIAGNENGIKNPSFYLYKEDQLTGLKQAMSQEEIQNKVDFMEFLAKNNAKLDNLSEKEKE
KFQTEIGNFQKDRKAYLDALGNDHIAFVFKKDPKHLALVTEFGNGEVSYTLKDYGKKQDKALDGETKTTL
QGNLKYDGVMFVNYSNFKYTNASKSPNKGLGATNGVSHLEANFSKVAVFNLPNLNNLAITNYIRRDLEDK
LWAKGLSPQEANKLIKDFLNSNKEMVGKVLNFNKAVAGAKNTGNYDEVKKAQKDLEKSLRKREHLEKEVA
KKLESRNDNKNRMEAKAQANSQKDKIFALINQEASKEARAVAFDPNLKGIRSELLDKLENINKNLKDFGK
SFDELKNGKNNDFSKAEETLKALKDSVKDLGINPEWISKIENLNAALNDFKNGKNKDFSKVTQAKSDLEN
SIKDVIINQKITDKVDNLNQAVSETKLTGNFSKVEQALAELKSLSLDLGKNSDLQKSVKNGVNGTLVGNG
LSKAEATTLTKNFSDIRKELNEKLFGNSNNNNNGLKNNTEPIYAQVNKKKAGQATSPEESVYAQVAKKVS
VKIDQLNEATSAINRKIDRINKIASAGKGVGGFSGAGRSASPEPIYATIDFDEANQVGFPLRRSAGVNDL
SKVGLSREQELTRRIGDLNQAVSEAKTGHFGNLEQKIDELKDSTKKNALKLWVESAKQVPTGLQAKLDNY
ATNSHTRINSNVQSGAINEKATGMLTQKNPEWLKLVNDKVVAHNVGSAPLSDYDKIGFNQKNMKDYSDSF
KFSTKLNNAVKDIKSSFVQFLTNTFSTGSYSLMKANVEHGVKNTTKSGFQKS
