VIOLIN: Vaccine Investigation and Online Information Network

ggt

General Information

Protegen ID

3921

Sequence Strain (Species/Organism)

Helicobacter pylori

Taxonomy ID

869727

Other Database IDs

CDD:129176

Molecule Role

Protective antigen

Molecule Role Annotation

The highest reduction in bacterial colonization was seen in mice immunized with the fusion protein rHspA-GGT when paired with the mucosal adjuvant LTB. Protection against H. pylori colonization was mediated by a strong systemic and localized humoral immune response (Zhang et al., 2015).

References

Zhang et al., 2015: Zhang X, Zhang J, Yang F, Wu W, Sun H, Xie Q, Si W, Zou Q, Yang Z. Immunization with Heat Shock Protein A and γ-Glutamyl Transpeptidase Induces Reduction on the Helicobacter pylori Colonization in Mice. PloS one. 2015; 10(6); e0130391. [PubMed: 26102080].

Gene Information

Gene Name

ggt

Protein Information

Protein Name

Gamma-glutamyl transpeptidase

NCBI Protein GI

ADN80237

Protein pI

9.66

Protein Weight

57541.42

Protein Length

645

Protein Note

gamma-glutamyltranspeptidase; TIGR00066

Protein Sequence

>ADN80237.1 Gamma-glutamyl transpeptidase [Helicobacter pylori 908]
MRRSFLKTIGLGVIALSLGLLNPLSAASYPPIKNTKVGLALSSHPLATEIGQKVLEEGGNAIDAAVAIGF
ALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTV
AGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAEILKEARERFLKYSSSKKYFFKKGHLDYQEGDL
FVQKDLAKTLNQIKTLGAKGFYQGQVADLIEKDMQKNGGIITKEDLASYNVKWRKPVIGSYRGYKIISMS
PPSSGGTHLIQILNVMENADLSALGYGASKNIHIVAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAK
KIFDAIQPDTVTPSSQIKPGMGQLHEGSNTTHYSVADRWGNAVSVTYTINASYGSAASIDGAGFLLNNEM
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMSPTIVLKNNKVFLVVGSPGGSRIITTVLQVISNVIDY
NMNISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIQVLPKTKGSVFYGS
TDPRKEF

Epitope Information

IEDB Linear Epitope