VIOLIN: Vaccine Investigation and Online Information Network

groEL

General Information

Protegen ID

3902

Sequence Strain (Species/Organism)

Bacillus anthracis

Taxonomy ID

1392

Molecule Role

Protective antigen

Molecule Role Annotation

(Sinha and Bhatnagar, 2013)

References

Sinha and Bhatnagar, 2013: Sinha K, Bhatnagar R. Recombinant GroEL enhances protective antigen-mediated protection against Bacillus anthracis spore challenge. Medical microbiology and immunology. 2013; 202(2); 153-165. [PubMed: 23263010].

Gene Information

Gene Name

groEL

Protein Information

Protein Name

molecular chaperone GroEL

NCBI Protein GI

KHA39277

Protein pI

4.52

Protein Weight

51999.08

Protein Length

610

Protein Note

60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; Derived by automated computational analysis using gene prediction method: Protein Homology.

Protein Sequence

>KHA39277.1 molecular chaperone GroEL [Bacillus anthracis]
MAKDIKFSEEARRSMLRGVDTLANAVKVTLGPKGRNVVLEKKFGSPLITNDGVTIAKEIELEDAFENMGA
KLVAEVASKTNDVAGDGTTTATVLAQAMIREGLKNVTAGANPMGLRKGIEKAVVAAVEELKTISKPIEGK
SSIAQVAAISAADEEVGQLIAEAMERVGNDGVITLEESKGFTTELDVVEGMQFDRGYASPYMITDSDKME
AVLDNPYILITDKKISNIQEILPVLEQVVQQGKPLLIIAEDVEGEALATLVVNKLRGTFNVVAVKAPGFG
DRRKAMLEDIAILTGGEVITEELGRDLKSATVESLGRAGKVVVTKENTTVVEGVGSTEQIEARIGQIRAQ
LEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKLRIEDALNSTRAAVEEGIVAGGGTSLMNV
YTKVASIVAEGDEATGINIVLRALEEPVRQIAINAGLEGSVVVERLKGEKVGVGFNAATGEWVNMLETGI
VDPAKVTRSALQNAASVAAMFLTTEAVVADKPEPNAPAMPDMGGMGGMGGMM

Epitope Information

IEDB Linear Epitope