An in vitro neutralization test revealed that sera from mice immunized with GWP (six nucleotide sequences encoding the immunodominant peptides from Adr2, YbgF and OmpB) reduced R. rickettsii adherence to, and invasion of, vascular endothelial cells(Wang et al., 2017).
The results indicated that proliferation and interferon (IFN)-γ secretion of CD4(+) or CD8(+) T cells in R. rickettsii-infected mice were significantly greater than in uninfected mice after stimulation with rYbgF. YbgF is a novel protective antigen of R. rickettsii (Gong et al., 2015).
References
Gong et al., 2015: Gong W, Qi Y, Xiong X, Jiao J, Duan C, Wen B. Rickettsia rickettsii outer membrane protein YbgF induces protective immunity in C3H/HeN mice. Human vaccines & immunotherapeutics. 2015; 11(3); 642-649. [PubMed: 25714655].
Wang et al., 2017: Wang P, Xiong X, Jiao J, Yang X, Jiang Y, Wen B, Gong W. Th1 epitope peptides induce protective immunity against Rickettsia rickettsii infection in C3H/HeN mice. Vaccine. 2017; 35(51); 7204-7212. [PubMed: 29032899].
